Evidence map›Paper›PMID 35075790›Full record

ArticleGenes, brain, and behavior2022

Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder.

Sophie Waldron, Rachel Pass, Simonas Griesius, Jack R Mellor, Emma S J Robinson, Kerrie L Thomas, Lawrence S Wilkinson, Trevor Humby, Jeremy Hall, Dominic M Dwyer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, brain, and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Quo Vadis translational neuroscience?Translational neuroscience · 2026
    Review
  2. Article
  3. Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sophie WaldronSchool of Psychology, Cardiff University, Cardiff, UK.
Rachel PassNeuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.
Simonas GriesiusCentre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, UK.
Jack R MellorCentre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, UK.
Emma S J RobinsonCentre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, UK.
Kerrie L ThomasNeuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.ORCID 0000-0003-3355-9583
Lawrence S WilkinsonSchool of Psychology, Cardiff University, Cardiff, UK.
Trevor HumbySchool of Psychology, Cardiff University, Cardiff, UK.
Jeremy HallNeuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.
Dominic M DwyerSchool of Psychology, Cardiff University, Cardiff, UK.ORCID 0000-0001-8069-5508
Cardiff University · GBUniversity of Bristol · GBCardiff Council · GBOkinawa Institute of Science and Technology Graduate University · JP

Funding

Medical Research Council G0801418Medical Research Council MR/L010305/1Wellcome Trust
6 · The paper itself

Abstract

Genetic studies implicate disruption to the DLG2 gene in copy number variants as increasing risk for schizophrenia, autism spectrum disorders and intellectual disability. To investigate psychiatric endophenotypes associated with DLG2 haploinsufficiency (and concomitant PSD-93 protein reduction) a novel clinically relevant Dlg2

Indexed as

Guanylate KinasesHaploinsufficiencySchizophreniaTumor Suppressor ProteinsAnimalsDisease Models, AnimalHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMicePhencyclidineRatsSocial BehaviorDLG2 protein, humanGuanylate KinasesIntracellular Signaling Peptides and ProteinsMembrane ProteinsMpp2 protein, ratPhencyclidineTumor Suppressor Proteinsanimal modelsautism spectrum disorderDLG2PCP locomotionschizophreniasensorimotor gatingsynaptic plasticity

Identifiers

PMID35075790
PMCPMC9393932
OpenAlexW4220766630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.