Evidence map›Paper›PMID 35075659›Full record

ArticleLipids2022

Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long-term cannabis users: A secondary analysis of a case-control study.

Giulia Cisbani, Alex Koppel, Adam H Metherel, Mackenzie E Smith, Kankana N Aji, Ana C Andreazza, Romina Mizrahi, Richard P Bazinet

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Giulia CisbaniDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-2947-2437
Alex KoppelDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
Adam H MetherelDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Mackenzie E SmithDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Kankana N AjiDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
Ana C AndreazzaDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
Romina MizrahiResearch Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
Richard P BazinetDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
University of Toronto · CACentre for Addiction and Mental Health · CA

Funding

Imaging Alterations in Endocannabinoid Metabolism in Clinical High Risk and First Episode PsychosisR01MH113564 · NIMH · MCGILL UNIVERSITY · PI MIZRAHI, ROMINA · 2017 to 2022
$2.2M
Imaging Neuroinflammation in Clinical high risk and SchizophreniaR01MH100043 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI MIZRAHI, ROMINA · 2014 to 2018
$1.6M
NIMH NIH HHS R01 MH100043NIMH NIH HHS R01 MH113564
6 · The paper itself

Abstract

Cannabis is now legal in many countries and while numerous studies have reported on its impact on cognition and appetite regulation, none have examined fatty acid metabolism in young cannabis users. We conducted an exploratory analysis to evaluate cannabis impact on fatty acid metabolism in cannabis users (n = 21) and non-cannabis users (n = 16). Serum levels of some saturated and monounsaturated fatty acids, including palmitic, palmitoleic, and oleic acids were higher in cannabis users compared to nonusers. As palmitic acid can be derived from diet or lipogenesis from sugars, we evaluated lipogenesis using a de novo lipogenesis index (palmitate/linoleic acid) and carbon-specific isotope analysis, which allows for the determination of fatty acid

Indexed as

CannabisLipogenesisCase-Control StudiesCytokinesFatty AcidsPalmitic AcidProspective StudiesPyruvic AcidCytokinesFatty AcidsPalmitic AcidPyruvic Acidcannabis useendocannabinoidsfatty acids/metabolismglucoseinflammationlipogenesispalmitic acid

Identifiers

PMID35075659
PMCPMC8923992
OpenAlexW4206994200

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.