Evidence map›Paper›PMID 35075581›Full record

ArticleJournal of gastrointestinal cancer2023

A Prospective Study Evaluating Health-Related Quality of Life Following a Multimodal Treatment for Colorectal Cancer.

Maria Perrone, Carlo Garufi, Maurizio Cosimelli, Franco Graziano, Chiara Falcicchio, Alessandro Bonucci, Luana Fotia, Diana Giannarelli, Luca Giacomelli, Gennaro Ciliberto and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Health-related quality of life trajectories in older adult long-term survivors of colorectal cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Maria PerronePsychology Unit, IRCCS Regina Elena Cancer Institute, Rome, Italy. maria.perrone@ifo.gov.it.
Carlo GarufiMedical Oncology, Azienda Ospedaliera San Camillo Forlanini Roma, Rome, Italy.
Maurizio CosimelliColon Rectal Surgery, Fondazione IRCCS Istituto Nazionale Dei Tumori, S.C. Oncological 2 , Milan, Italy.
Franco GrazianoDepartment of Surgery, IRCCS Regina Elena Cancer Institute, Rome, Italy.
Chiara FalcicchioPsychology Unit, IRCCS Regina Elena Cancer Institute, Rome, Italy.
Alessandro BonucciPsychology Unit, IRCCS Regina Elena Cancer Institute, Rome, Italy.
Luana FotiaPsychology Unit, IRCCS Regina Elena Cancer Institute, Rome, Italy.
Diana GiannarelliBiostatistics Unit, IRCCS Regina Elena Cancer Institute, Rome, Italy.
Luca GiacomelliPolistudium SRL, Milan, Italy.
Gennaro CilibertoScientific Direction, IRCCS Regina Elena Cancer Institute, Rome, Italy.
Patrizia PugliesePsychology Unit, IRCCS Regina Elena Cancer Institute, Rome, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITAzienda Ospedaliera San Camillo-Forlanini · ITFondazione IRCCS Istituto Nazionale dei Tumori · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe major improvements in the diagnosis and treatment of colorectal cancer (CRC) over the past decades increased the patients' survival rates. Despite this, patients and clinicians still need to address the long-term physical and psychosocial effects over time. This paper aims to prospectively assess CRC patients' HR-QoL psychological distress and sexual functioning and identify clinical, demographic, and psychological predictors.

methodsIn total, 55 patients were evaluated from diagnosis to 5-year follow-up with the following instruments: EORTC QLQ-C30 and QLQ-C38 for QoL and sexuality; HADS for psychological distress; and specific questions to detect psychological variables.

resultsQoL worsened after diagnosis and returned to baseline values after 5 years. Sexual function significantly deteriorated over time (with no recovery, especially in women), while borderline/severe anxiety and depression decreased. A better HR-QoL at baseline was associated with better physical, social and sexual functioning, positive body image and sexual pleasure after 5 years.

conclusionHR-QoL allows the early detection of patients at risk, favoring prompt patient-centered interventions.

Indexed as

Colorectal NeoplasmsQuality of LifeCombined Modality TherapyFemaleHumansProspective StudiesSurveys and QuestionnairesColorectal cancer multimodal treatmentColorectal cancer surgeryPsychological distressQuality of lifeSexuality

Identifiers

PMID35075581
OpenAlexW4206906343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.