Evidence map›Paper›PMID 35075519›Full record

ArticleApplied microbiology and biotechnology2022

Transcriptome analysis reveals the underlying mechanism of heptanal against Aspergillus flavus spore germination.

Sheng-Fa Li, Shuai-Bing Zhang, Yang-Yong Lv, Huan-Chen Zhai, Yuan-Sen Hu, Jing-Ping Cai

Abstract read
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In one paragraph

Article in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sheng-Fa LiCollege of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Zhengzhou, Henan, 450001, People's Republic of China.
Shuai-Bing ZhangCollege of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Zhengzhou, Henan, 450001, People's Republic of China. shbzhang@163.com.ORCID http://orcid.org/0000-0002-1770-3322
Yang-Yong LvCollege of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Zhengzhou, Henan, 450001, People's Republic of China.
Huan-Chen ZhaiCollege of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Zhengzhou, Henan, 450001, People's Republic of China.
Yuan-Sen HuCollege of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Zhengzhou, Henan, 450001, People's Republic of China.
Jing-Ping CaiCollege of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Zhengzhou, Henan, 450001, People's Republic of China. caijp163@163.com.
Henan University of Technology · CN

Funding

National Natural Science Foundation of China 31772023
6 · The paper itself

Abstract

Methods of controlling Aspergillus flavus contamination in agro-products have attracted attention because of its impact on global food security. We previously reported that the natural cereal volatile heptanal could effectively inhibit A. flavus growth and showed great potential as a bio-preservative agent. In this study, the minimum inhibitory concentration and minimum fungicide concentration of heptanal could change the surface morphology of A. flavus spores, causing them to wrinkle and collapse. Transcriptomic analysis showed that heptanal treatment significantly changed the expression of several genes involved in cell wall and plasma damage, reactive oxygen species (ROS) accumulation, energy metabolism, AMPK-activated protein kinase, biosynthesis of unsaturated fatty acids, RNA degradation, and DNA replication. Heptanal-induced early apoptosis of A. flavus spores was characterized by decreased mitochondrial membrane potential, increased intracellular ROS production, and DNA fragmentation. This study provides new insight into the inhibitory mechanism of heptanal against A. flavus and points to its potential application as a bio-preservative. KEY POINTS: • Heptanal can effectively inhibit A. flavus growth in cereal grains. • The transcriptional changes in A. flavus spores exposed to heptanal were analyzed. • The antifungal mechanism of heptanal against A. flavus was elucidated.

Indexed as

AldehydesAspergillus flavusAntifungal AgentsGene Expression ProfilingSpores, FungalAldehydesAntifungal AgentsheptanalAMPKAntifungal mechanismAspergillus flavusHeptanalTranscriptomics

Identifiers

PMID35075519
OpenAlexW4207052309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.