Evidence map›Paper›PMID 35075518›Full record

ArticleHNO2022

[Otorhinolaryngological diseases in pregnancy-which drugs are approved?]

W E Paulus, J Lindemann, U Friebe-Hoffmann

Abstract read
PubMed Publisher
In one paragraph

Article in HNO, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

W E PaulusKlinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Ulm, Ulm, Deutschland. paulus@reprotox.de.
J LindemannKlinik für Hals-Nasen-Ohrenheilkunde und Kopf-Hals-Chirurgie, Universitätsklinikum Ulm, Ulm, Deutschland.
U Friebe-HoffmannKlinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Ulm, Ulm, Deutschland.
University Hospital Ulm · DEUniversitätsklinik für Hals-, Nasen- und Ohrenheilkunde · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Between 1958 and 1961 approximately 10,000 children with severe deformities of extremities were born, whose mothers had taken the sedative thalidomide. Since then, drugs in pregnancy are applied with legitimate caution by the pharmaceutical industry, physicians and patients, although often accompanied by irrational panic. The pharmaceutical industry takes a legally safe position noting "contraindication" or at least "strict indication" in the consumer information. This transfers responsibility to the prescribing doctor. Even without drug therapy, the spontaneous malformation rate is approx. 3 to 4%. Concerning expectant mothers, a therapeutic nihilism may lead to a dramatic deterioration of the maternal disease, thereby causing high risks in fetal development. The aim of the present work is to present a structured "Guideline for Practice" of medication that can be used during pregnancy for treating medical conditions of the ear, nose and throat.

Indexed as

Otorhinolaryngologic DiseasesPharmaceutical PreparationsChildFemaleHumansPregnancyThalidomidePharmaceutical PreparationsThalidomideAbnormalities, drug-inducedAllergyCongenital abnormalitiesPharmacotherapyTeratogens

Identifiers

PMID35075518
OpenAlexW4207010494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.