Evidence map›Paper›PMID 35075502›Full record

ArticleMetabolic brain disease2022

Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (Alzheimer model) in rat.

Shaymaa Rezk, Samah Lashen, Mohamed El-Adl, Gehad E Elshopakey, Mona M Elghareeb, Basma M Hendam, Thomas Caceci, Carlo Cenciarelli, Hany E Marei

RetractedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Deciphering Neuroprotective Effect ofCurrent drug targets · 2024
    Review
  3. Article
  4. Frontiers in pharmacology · 2022
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Shaymaa RezkDepartment of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Samah LashenDepartment of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Mohamed El-AdlDepartment of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Gehad E ElshopakeyDepartment of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. gehadelshobaky@yahoo.com.ORCID http://orcid.org/0000-0003-2924-9670
Mona M ElghareebDepartment of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Basma M HendamDepartment of Husbandry & Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Thomas CaceciBiomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine , Blacksburg, VA, USA.
Carlo CenciarelliDepartament of Biomedical Sciences, Institute of Translational Pharmacology-CNR, Rome, Italy.
Hany E MareiDepartment of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Mansoura University · EGIstituto di Farmacologia Traslazionale · ITVirginia–Maryland College of Veterinary Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rosemary oil (ROO) is known to have multiple pharmacological effects: it is an antioxidant, anti-inflammatory, and cytoprotective. In the present study, we examined the effects of ROO on Human olfactory bulb neuronal stem cells (hOBNSCs) after their transplantation into rats, with the ibotenic (IBO) acid-induced cognitive deficit model. After 7 weeks, cognitive functions were assessed using the Morris water maze (MWM). After two months blood and hippocampus samples were collected for biochemical, gene expression, and histomorphometric analyses. Learning ability and memory function were significantly enhanced (P < 0.05) after hOBNSCs transplantation and were nearly returned to normal in the treated group. The IBO acid injection was associated with a significant decline (P < 0.05) of total leukocyte count (TLC) and a significant increase (P < 0.05) in total and toxic neutrophils. As well, the level of IL-1β, TNF-α CRP in serum and levels of MDA and NO in hippocampus tissue were significantly elevated (P < 0.05), while antioxidant markers (CAT, GSH, and SOD) were reduced (P < 0.05) in treated tissue compared to controls. The administration of ROO before or with cell transplantation attenuated all these parameters. In particular, the level of NO nearly returned to normal when rosemary was administrated before cell transplantation. Gene expression analysis revealed the potential protective effect of ROO and hOBNSCs via down-expression of R-βAmyl and R- CAS 3 and R-GFAP genes. The improvement in the histological organization of the hippocampus was detected after the hOBNSCs transplantation especially in h/ROO/hOBNSCs group.

Indexed as

Alzheimer DiseaseNeural Stem CellsNeurotoxicity SyndromesRosmarinusAnimalsAntioxidantsDietary SupplementsHumansIbotenic AcidMaze LearningOils, VolatileOlfactory BulbRatsAntioxidantsIbotenic AcidOils, Volatilerosemary oilAlzheimer’s diseaseGene expressionImmunocytochemistryOlfactory bulb neural stem cellsRosemary oil

Identifiers

PMID35075502
OpenAlexW4220965391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.