ArticleCritical care research and practice2022
Major Bleeding in Adults Undergoing Peripheral Extracorporeal Membrane Oxygenation (ECMO): Prognosis and Predictors.
Article in Critical care research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Meta-Analysis of Durable Compared to Temporary Left Ventricular Assist Devices Compared to Venoarterial Extracorporeal Membrane Oxygenation for Bridging to Heart Transplantation or Treatment of Primary Graft Dysfunction.Reviews in cardiovascular medicine · 2025Pooled it
- Challenges and opportunities in ECMO monitoring: A mixed-methods appraisal.The journal of extra-corporeal technology · 2026Review
- Extracorporeal Life Support in Severe Accidental Hypothermia: Mechanisms, Challenges and Clinical Horizons.Journal of clinical medicine · 2026Review
- Clinical correlates for major bleeding during veno-arterial extracorporeal membrane oxygenation support: a time-dependent perspective.Critical care (London, England) · 2026Article
- Dynamic platelet dysfunction during extracorporeal membrane oxygenation: a pilot study.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Ovarian Hemorrhage as a Complication of Venovenous Extracorporeal Membrane Oxygenation.O&G open · 2025Article
- Activated Clotting Time and Haemostatic Complications in Patients Receiving ECMO Support: A Systematic Review.Journal of cardiovascular development and disease · 2025Review
- [Special aspects of patients with va-ECMO on the way to organ donation].Die Anaesthesiologie · 2025Review
- Review
- Optimising fluid therapy during venoarterial extracorporeal membrane oxygenation: current evidence and future directions.Annals of intensive care · 2025Review
- Pharmacokinetic and pharmacodynamic analyses of nafamostat in ECMO patients: comparing central vein and ECMO machine samples.Frontiers in pharmacology · 2025Article
- Observational
- A patient with acute pulmonary embolism caused by hyaluronic acid injection underwent nursing care of extracorporeal membrane oxygenation support therapy: a case report.Frontiers in medicine · 2025Article
- Anticoagulation and associated complications in veno-arterial extracorporeal membrane oxygenation in adult patients: A systematic review and meta-analysis.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Review
- Inferior vena cava thrombosis in patients undergoing extracorporeal membrane oxygenation: a case series and literature review.BMC anesthesiology · 2024Article
- Transarterial embolization to treat a massive hemothorax during mechanical circulatory support via puncturing of the extracorporeal membrane oxygenation circuit.CVIR endovascular · 2024Article
- Extracorporeal Membrane Oxygenation (ECMO)-Associated Coagulopathy in Adults.Diagnostics (Basel, Switzerland) · 2023Review
- Update on Anticoagulation Strategies in Patients with ECMO-A Narrative Review.Journal of clinical medicine · 2023Review
- Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis.Thrombosis and haemostasis · 2023Article
- Comparison of Blood and Blood Product Transfusion in COVID-19 and Non-COVID-19 Patients Requiring Extracorporeal Membrane Oxygenation for Severe Respiratory Failure.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor bleeding has been a common and serious complication with poor outcomes in ECMO patients. With a novel, less-invasive cannulation approach and closer coagulation monitoring regime, the incidence of major bleeding is currently not determined yet. Our study aims to examine the incidence of major bleeding, its determinants, and association with mortality in peripheral-ECMO patients.
methodWe conducted a single-center retrospective study on adult patients undergoing peripheral-ECMO between January 2019 and January 2020 at a tertiary referral hospital. Determinants of major bleeding were defined by logistic regression analysis. Risk factors of in-hospital mortality were determined by Cox proportional hazard regression analysis.
resultsMajor bleeding was reported in 33/105 patients (31.4%) and was associated with higher in-hospital mortality [adjusted hazard ratio (aHR) 3.56, 95% confidence interval (CI) 1.63-7.80,
conclusionsIn summary, major bleeding still had a fairly high incidence and poor outcome in peripheral-ECMO patients. APTT > 72 seconds, fibrinogen < 2 g/L were the strongest predicting factors for major bleeding events.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.