ArticleThe European physical journal. Special topics2022
Dynamical demeanour of SARS-CoV-2 virus undergoing immune response mechanism in COVID-19 pandemic.
Article in The European physical journal. Special topics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Modelling and investigating memory immune responses in infectious disease. Application to influenza a virus and sars-cov-2 reinfections.Infectious Disease Modelling · 2025Article
- Review
- Stability of a delayed SARS-CoV-2 reactivation model with logistic growth and adaptive immune response.Physica A · 2023Article
- The spatial dynamics of immune response upon virus infection through hybrid dynamical computational model.Frontiers in immunology · 2023Article
- Clinical effects of 2-DG drug restraining SARS-CoV-2 infection: A fractional order optimal control study.Journal of biological physics · 2022Article
- Timely and effective media coverage's role in the spread of Corona Virus Disease 2019.Mathematical methods in the applied sciences · 2022Article
- Early Prediction Model for Critical Illness of Hospitalized COVID-19 Patients Based on Machine Learning Techniques.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
COVID-19 is caused by the increase of SARS-CoV-2 viral load in the respiratory system. Epithelial cells in the human lower respiratory tract are the major target area of the SARS-CoV-2 viruses. To fight against the SARS-CoV-2 viral infection, innate and thereafter adaptive immune responses be activated which are stimulated by the infected epithelial cells. Strong immune response against the COVID-19 infection can lead to longer recovery time and less severe secondary complications. We proposed a target cell-limited mathematical model by considering a saturation term for SARS-CoV-2-infected epithelial cells loss reliant on infected cells level. The analytical findings reveal the conditions for which the system undergoes transcritical bifurcation and alternation of stability for the system around the steady states happens. Due to some external factors, while the viral reproduction rate exceeds its certain critical value, backward bifurcation and reinfection may take place and to inhibit these complicated epidemic states, host immune response, or immunopathology would play the essential role. Numerical simulation has been performed in support of the analytical findings.
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Registered trials
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