Evidence map›Paper›PMID 35075381›Full record

Observational studyCanadian respiratory journal2022

Predictors of Helmet CPAP Failure in COVID-19 Pneumonia: A Prospective, Multicenter, and Observational Cohort Study.

Pierachille Santus, Stefano Pini, Francesco Amati, Marina Saad, Marina Gatti, Michele Mondoni, Francesco Tursi, Maurizio Rizzi, Davide Alberto Chiumello, Valter Monzani and 3 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Canadian respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Longitudinal Assessment of ROX and HACOR Scores to Predict Non-Invasive Ventilation Failure in Patients with SARS-CoV-2 Pneumonia.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pierachille SantusDivision of Respiratory Diseases, Ospedale Luigi Sacco, Polo Universitario, ASST Fatebenefratelli-Sacco, Milano, Italy.ORCID 0000-0003-3462-8253
Stefano PiniDivision of Respiratory Diseases, Ospedale Luigi Sacco, Polo Universitario, ASST Fatebenefratelli-Sacco, Milano, Italy.ORCID 0000-0002-3084-4365
Francesco AmatiRespiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.ORCID 0000-0002-8248-7785
Marina SaadDivision of Respiratory Diseases, Ospedale Luigi Sacco, Polo Universitario, ASST Fatebenefratelli-Sacco, Milano, Italy.
Marina GattiDivision of Respiratory Diseases, Ospedale Luigi Sacco, Polo Universitario, ASST Fatebenefratelli-Sacco, Milano, Italy.
Michele MondoniRespiratory Unit, ASST Santi Paolo e Carlo, San Paolo Hospital, Milano, Italy.ORCID 0000-0001-9672-3534
Francesco TursiUOS Pneumologia, Ospedale Civico di Codogno, ASST Lodi, Lodi, Italy.
Maurizio RizziDivision of Respiratory Diseases, Ospedale Luigi Sacco, Polo Universitario, ASST Fatebenefratelli-Sacco, Milano, Italy.
Davide Alberto ChiumelloDipartimento di Scienze Della Salute, Università degli Studi di Milano, Milano, Italy.ORCID 0000-0001-9260-3930
Valter MonzaniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Medicine, Acute Medical Unit, Milano, Italy.
Francesco BlasiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Respiratory Unit and Cystic Fibrosis Adult Center, Milano, Italy.ORCID 0000-0002-2285-9970
Stefano AlibertiRespiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.ORCID 0000-0002-0090-4531
Dejan RadovanovicDivision of Respiratory Diseases, Ospedale Luigi Sacco, Polo Universitario, ASST Fatebenefratelli-Sacco, Milano, Italy.ORCID 0000-0002-9013-3418

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Continuous positive airway pressure (CPAP) can be beneficial in acute respiratory failure (ARF) due to coronavirus (COVID-19) pneumonia, but delaying endotracheal intubation (ETI) in nonresponders may increase mortality. We aimed at investigating the performance of composite respiratory indexes as possible predictors of CPAP failure in ARF due to COVID-19. Methods: This was a multicenter, prospective, observational, and cohort study conducted in the respiratory units of three University hospitals in Milan and in a secondary care hospital in Codogno (Italy), on consecutive adult patients with ARF due to COVID-19 pneumonia that underwent CPAP between March 2020 and March 2021. ETI transfer to the intensive care unit or death is defined CPAP failure. Predictors of CPAP failure were assessed before T0 and 1 hour after T1 CPAP initiation and included mROX index (ratio of PaO2/FiO2 to respiratory rate), alveolar-to-arterial (A-a) O Results: Three hundred and fifty four patients (mean age 64 years, 73% males) were included in the study; 136 (38.4%) satisfied criteria for CPAP failure. A-a O Conclusions: The HACOR score may be a reliable and early predictor of CPAP failure in patients treated for ARF in COVID-19 pneumonia.

Indexed as

COVID-19PneumoniaRespiratory InsufficiencyAdultCohort StudiesContinuous Positive Airway PressureFemaleHumansMaleMiddle AgedProspective StudiesSARS-CoV-2

Identifiers

PMID35075381
PMCPMC8783135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.