Evidence map›Paper›PMID 35075194›Full record

ArticleScientific reports2022

Evidence of plasma biomarkers indicating high risk of dementia in cognitively normal subjects.

Ming-Chyi Pai, Chau-Chung Wu, Yi-Chou Hou, Jiann-Shing Jeng, Sung-Chun Tang, Wei-Che Lin, Cheng-Hsien Lu, Ming-Jang Chiu, Ta-Fu Chen, Sui-Hing Yan and 2 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  7. Elevated C-Reactive Protein in Older Men With Chronic Pain: Association With Plasma Amyloid Levels and Hippocampal Volume.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Ming-Chyi PaiDivision of Behavioral Neurology, Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.
Chau-Chung WuDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100, Taiwan.
Yi-Chou HouGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan.
Jiann-Shing JengDepartment of Neurology, National Taiwan University Hospital, Taipei, 100, Taiwan.
Sung-Chun TangDepartment of Neurology, National Taiwan University Hospital, Taipei, 100, Taiwan.
Wei-Che LinDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 833, Taiwan.
Cheng-Hsien LuDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 833, Taiwan.
Ming-Jang ChiuDepartment of Neurology, National Taiwan University Hospital, Taipei, 100, Taiwan.
Ta-Fu ChenDepartment of Neurology, National Taiwan University Hospital, Taipei, 100, Taiwan.
Sui-Hing YanDepartment of Neurology, Far Eastern Memorial Hospital, New Taipei City, 220, Taiwan.
Chaur-Jong HuDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 106, Taiwan.
Shieh-Yueh YangMagQu Co., Ltd., New Taipei City, 231, Taiwan. syyang@magqu.com.
National Taiwan University Hospital · TWChang Gung University · TWFar Eastern Memorial Hospital · TWFu Jen Catholic University · TWKaohsiung Chang Gung Memorial Hospital · TWNational Cheng Kung University Hospital · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subjects with comorbidities are at risk for neurodegeneration. There is a lack of a direct relationship between comorbidities and neurodegeneration. In this study, immunomagnetic reduction (IMR) assays were utilized to assay plasma Aβ

Indexed as

AdultAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersCase-Control StudiesCognitionDementiaDiabetes ComplicationsFemaleHumansKidney Failure, ChronicMaleMiddle AgedPeptide FragmentsRisk AssessmentAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersMAPT protein, humanPeptide Fragmentstau Proteins

Identifiers

PMID35075194
PMCPMC8786959
OpenAlexW4206920429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.