Evidence map›Paper›PMID 35075153›Full record

ArticleScientific reports2022

The application of a deep learning system developed to reduce the time for RT-PCR in COVID-19 detection.

Yoonje Lee, Yu-Seop Kim, Da-In Lee, Seri Jeong, Gu-Hyun Kang, Yong Soo Jang, Wonhee Kim, Hyun Young Choi, Jae Guk Kim, Sang-Hoon Choi

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yoonje Lee *Department of Emergency Medicine, College of Medicine, Hallym University, Chuncheon, South Korea.
Yu-Seop Kim *Department of Convergence Software, Hallym University, Chuncheon, South Korea.
Da-In LeeDepartment of Convergence Software, Hallym University, Chuncheon, South Korea.
Seri JeongDepartment of Laboratory Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 6, Singil-ro, 1-gil, Youngdeungpo-gu, Seoul, 07441, South Korea. hehebox@naver.com.ORCID 0000-0002-4199-7033
Gu-Hyun KangDepartment of Emergency Medicine, College of Medicine, Hallym University, Chuncheon, South Korea.
Yong Soo JangDepartment of Emergency Medicine, College of Medicine, Hallym University, Chuncheon, South Korea.
Wonhee KimDepartment of Emergency Medicine, College of Medicine, Hallym University, Chuncheon, South Korea.
Hyun Young ChoiDepartment of Emergency Medicine, College of Medicine, Hallym University, Chuncheon, South Korea.
Jae Guk KimDepartment of Emergency Medicine, College of Medicine, Hallym University, Chuncheon, South Korea.
Sang-Hoon ChoiHallym Bioinformatics & Convergence Research Laboratory, Hallym Translation Research Center, Kangnam Sacred-Heart Hospital, Hallym University, Chuncheon, South Korea.

Funding

Hallym University Research Fund HURF-2020-64
6 · The paper itself

Abstract

Reducing the time to diagnose COVID-19 helps to manage insufficient isolation-bed resources and adequately accommodate critically ill patients. There is currently no alternative method to real-time reverse transcriptase polymerase chain reaction (RT-PCR), which requires 40 cycles to diagnose COVID-19. We propose a deep learning (DL) model to improve the speed of COVID-19 RT-PCR diagnosis. We developed and tested a DL model using the long short-term memory method with a dataset of fluorescence values measured in each cycle of 5810 RT-PCR tests. Among the DL models developed here, the diagnostic performance of the 21st model showed an area under the receiver operating characteristic (AUROC), sensitivity, and specificity of 84.55%, 93.33%, and 75.72%, respectively. The diagnostic performance of the 24th model showed an AUROC, sensitivity, and specificity of 91.27%, 90.00%, and 92.54%, respectively.

Indexed as

COVID-19COVID-19 Nucleic Acid TestingDeep LearningReverse Transcriptase Polymerase Chain ReactionHumansSARS-CoV-2Sensitivity and Specificity

Identifiers

PMID35075153
PMCPMC8786863

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.