Evidence map›Paper›PMID 35075147›Full record

ArticleScientific reports2022

Clinical factors and outcomes associated with immune non-response among virally suppressed adults with HIV from Africa and the United States.

Adi Noiman, Allahna Esber, Xun Wang, Emmanuel Bahemana, Yakubu Adamu, Michael Iroezindu, Francis Kiweewa, Jonah Maswai, John Owuoth, Lucas Maganga and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Adi NoimanInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. anoiman@idcrp.org.
Allahna EsberHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Xun WangInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Emmanuel BahemanaUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Yakubu AdamuUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Michael IroezinduUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Francis KiweewaMakerere University Walter Reed Project, Kampala, Uganda.
Jonah MaswaiUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
John OwuothUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Lucas MagangaNational Institute of Medical Research-Mbeya Medical Research Centre, Mbeya, Tanzania.
Anuradha GanesanInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Ryan C MavesNaval Medical Center San Diego, San Diego, CA, USA.
Tahaniyat LalaniInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Rhonda E ColomboInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Jason F OkuliczInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Christina PolyakHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Trevor A CrowellUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Julie A AkeUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Brian K AganInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. bagan@idcrp.org.

Funding

Henry M. Jackson Foundation W81XWH-18-2-0040National Institute of Allergy and Infectious Diseases Y1-AI-5072NIAID NIH HHS Y01 AI005072PEPFARU.S. Department of Defense HU0001190002
6 · The paper itself

Abstract

A significant minority of people living with HIV (PLWH) achieve viral suppression (VS) on antiretroviral therapy (ART) but do not regain healthy CD4 counts. Clinical factors affecting this immune non-response (INR) and its effect on incident serious non-AIDS events (SNAEs) have been challenging to understand due to confounders that are difficult to control in many study settings. The U.S. Military HIV Natural History Study (NHS) and African Cohort Study (AFRICOS). PLWH with sustained VS (< 400 copies/ml for at least two years) were evaluated for INR (CD4 < 350 cells/µl at the time of sustained VS). Logistic regression estimated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for factors associated with INR. Cox proportional hazards regression produced adjusted hazard ratios (aHRs) for factors associated with incident SNAE after sustained VS. INR prevalence was 10.8% and 25.8% in NHS and AFRICOS, respectively. Higher CD4 nadir was associated with decreased odds of INR (aOR = 0.34 [95% CI 0.29, 0.40] and aOR = 0.48 [95% CI 0.40, 0.57] per 100 cells/µl in NHS and AFRICOS, respectively). After adjustment, INR was associated with a 61% increase in relative risk of SNAE [95% CI 1.12, 2.33]. Probability of "SNAE-free" survival at 15 years since sustained VS was approximately 20% lower comparing those with and without INR; nearly equal to the differences observed by 15-year age groups. CD4 monitoring before and after VS is achieved can help identify PLWH at risk for INR. INR may be a useful clinical indicator of future risk for SNAEs.

Indexed as

AdultAfricaAnti-Retroviral AgentsFemaleHIV InfectionsHumansLongitudinal StudiesMaleUnited StatesAnti-Retroviral Agents

Identifiers

PMID35075147
PMCPMC8786968

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.