Evidence map›Paper›PMID 35075130›Full record

ArticleBone research2022

PDGFRα reporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair.

Jiajia Xu, Yiyun Wang, Zhu Li, Ye Tian, Zhao Li, Amy Lu, Ching-Yun Hsu, Stefano Negri, Cammy Tang, Robert J Tower and 2 more

Open access · goldAbstract read
In one paragraph

Article in Bone research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Youthfulness of marrow AdipoqBone research · 2026
    Article
  5. Article
  6. Clec3bBone research · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Stage-resolved geography of mouse skeletal stem cells.Journal of bone and mineral metabolism · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. The Periosteum in Health and Disease.Current osteoporosis reports · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Jiajia Xu *Departments of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0002-6084-2029
Yiyun Wang *Departments of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0003-0775-4377
Zhu LiDepartments of Orthopedics, Johns Hopkins University, Baltimore, MD, 21205, USA.
Ye TianDepartments of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Zhao LiDepartments of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Amy LuDepartments of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Ching-Yun HsuDepartments of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Stefano NegriDepartments of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Cammy TangDepartments of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Robert J TowerDepartments of Orthopedics, Johns Hopkins University, Baltimore, MD, 21205, USA.
Carol MorrisDepartments of Orthopedics, Johns Hopkins University, Baltimore, MD, 21205, USA.
Aaron W JamesDepartments of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA. awjames@jhmi.edu.ORCID http://orcid.org/0000-0002-2002-622X
Johns Hopkins University · US

Funding

Direct and indirect contributions of perivascular stem cells to bone healingR01AR070773 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JAMES, AARON W · 2017 to 2021
$1.4M
Role of sensory nerves in cranial bone repairR21DE027922 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI CLEMENS, THOMAS L, JAMES, AARON W · 2018 to 2019
$450k
American Cancer Society (American Cancer Society, Inc.) Research Scholar Grant, RSG-18-027-01-CSMNIAMS NIH HHS R01 AR070773NIDCR NIH HHS R21 DE027922U.S. Department of Defense (United States Department of Defense) W81XWH-18-1-0121U.S. Department of Defense (United States Department of Defense) W81XWH-18-1-0336U.S. Department of Defense (United States Department of Defense) W81XWH-18-10613U.S. Department of Defense (United States Department of Defense) W81XWH-20-1-0302
6 · The paper itself

Abstract

The outer coverings of the skeleton, which is also known as the periosteum, are arranged in concentric layers and act as a reservoir for tissue-specific bone progenitors. The cellular heterogeneity within this tissue depot is being increasingly recognized. Here, inducible PDGFRα reporter animals were found to mark a population of cells within the periosteum that act as a stem cell reservoir for periosteal appositional bone formation and fracture repair. During these processes, PDGFRα reporter

Identifiers

PMID35075130
PMCPMC8786977
OpenAlexW4206959932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.