ReviewTranslational psychiatry2022
Functional neuroanatomy of mania.
Review in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hemispheric Asymmetries in Bipolar Disorder: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Effectiveness of transcranial direct current stimulation on emotional instability and impulsivity in atypical depression and bipolar II disorder.Scientific reports · 2025Trial
- Magnetic Seizure Therapy vs Modified Electroconvulsive Therapy in Patients With Bipolar Mania: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Risk Factors Associated with Longitudinal Trajectories of Mania Symptoms in Youth.medRxiv : the preprint server for health sciences · 2026Article
- Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner.Neuroscience bulletin · 2026Article
- Distinct and common subcortical functional connectivity revealed across three major psychiatric disorders.Psychological medicine · 2026Article
- Left and Right Hemispheric Lateralization as an Overlooked Variable in Psychiatric Disease: Evidence Across Species.Biological psychiatry · 2026Review
- Alice in Wonderland and Ekbom Syndromes in a Bipolar I Manic Episode: A Case Report With Neuroimaging Findings.Case reports in psychiatry · 2026Article
- Differences in the Efficacy of Cognitive Function Treatment Related to Functional Patterns in the Frontal-Limbic Network in Patients With Bipolar Disorder.CNS neuroscience & therapeutics · 2026Article
- Dopamine and Mood in Psychotic Disorders: An 18F-DOPA PET Study.JAMA psychiatry · 2025Article
- Exploring the Potential Psychopharmacological Mechanisms Behind the Manicogenic Properties of Clozapine.Psychopharmacology bulletin · 2025Article
- Development and validation of a dynamic nomogram to predict alexithymia in young and middle aged stroke patients.Scientific reports · 2025Article
- Behavioral manifestations and underlying mechanisms of amphetamine in constructing animal models of mania: a comprehensive review.Frontiers in neuroscience · 2025Review
- Alterations of subcortical structure volume in pediatric bipolar disorder patients with manic or depressive first-episode.BMC psychiatry · 2024Article
- Steroid-induced mania in a patient with previously well-controlled organic bipolar 1-like affective disorder secondary to acquired brain injury: case report and literature review.Discover mental health · 2024Article
- Structural and temporal dynamics analysis of neural circuit from 2002 to 2022: A bibliometric analysis.Heliyon · 2024Review
- Imbalanced motivated behaviors according to motor sign asymmetry in drug-naïve Parkinson's disease.Scientific reports · 2023Article
- Regulatory Clearance and Approval of Therapeutic Protocols of Transcranial Magnetic Stimulation for Psychiatric Disorders.Brain sciences · 2023Review
- Mania-related effects on structural brain changes in bipolar disorder - a narrative review of the evidence.Molecular psychiatry · 2023Review
- The Brain Overwork Scale: A Population-Based Cross-Sectional Study on the Psychometric Properties of a New 10-Item Scale to Assess Mental Distress in Mongolia.Healthcare (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mania, the diagnostic hallmark of bipolar disorder, is an episodic disturbance of mood, sleep, behavior, and perception. Improved understanding of the neurobiology of mania is expected to allow for novel avenues to address current challenges in its diagnosis and treatment. Previous research focusing on the impairment of functional neuronal circuits and brain networks has resulted in heterogenous findings, possibly due to a focus on bipolar disorder and its several phases, rather than on the unique context of mania. Here we present a comprehensive overview of the evidence regarding the functional neuroanatomy of mania. Our interpretation of the best available evidence is consistent with a convergent model of lateralized circuit dysfunction in mania, with hypoactivity of the ventral prefrontal cortex in the right hemisphere, and hyperactivity of the amygdala, basal ganglia, and anterior cingulate cortex in the left hemisphere of the brain. Clarification of dysfunctional neuroanatomic substrates of mania may contribute not only to improve understanding of the neurobiology of bipolar disorder overall, but also highlights potential avenues for new circuit-based therapeutic approaches in the treatment of mania.
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