ReviewActa bio-medica : Atenei Parmensis2022
More than meets the eye: A case of synchronous ipsilateral clear cell renal cell carcinoma and urothelial carcinoma of the pelvicalyceal system and literature review.
Review in Acta bio-medica : Atenei Parmensis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 15 citations in OpenAlex.
- Long pedunculated tumor from the ureteral stump protruding into the bladder after nephrectomy: a case report.Discover oncology · 2026Article
- Primary bladder diffuse large B-cell lymphoma: A rare case report.International journal of surgery case reports · 2025Article
- Simultaneous laparoscopic management of dual primary malignancies: case reports and literature review of synchronous renal cell carcinoma and colon carcinoma of sigmoid.Journal of surgical case reports · 2025Article
- Synchronous Ipsilateral Occurrence of Advanced Renal Pelvic Urothelial Carcinoma With Lung Metastasis and Localized Renal Cell Carcinoma: A Case Report.Clinical case reports · 2025Article
- Surgical management of giant retroperitoneal liposarcoma: a case report and review of the literature.Journal of surgical case reports · 2025Article
- Urinary bladder paraganglioma in pregnancy: a case report and literature review.Frontiers in medicine · 2025Article
- Urinary bladder paraganglioma presenting with abdominal pain and elevated cardiac enzymes: a case report of atypical manifestations and diagnostic challenges.Frontiers in oncology · 2025Article
- Renal Endometriosis Mimics Renal Cell Carcinoma in a Hypoplastic Kidney: A Case Report.Cureus · 2024Article
- Autosomal dominant polycystic kidney disease with ectopic unilateral multicystic kidney: a case report.Journal of medical case reports · 2024Article
- Synchronous ipsilateral papillary renal cell carcinoma and urothelial carcinoma: A case report.Oncology letters · 2023Article
- Chromophobe renal cell carcinoma with ipsilateral ureteral urothelial carcinoma: A case report.Molecular and clinical oncology · 2023Article
- Robot-assisted ipsilateral partial nephrectomy with distal ureterectomy for synchronous renal and ureteric tumors-a case report.Journal of the Egyptian National Cancer Institute · 2022Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimThe synchronous occurrence of renal cell carcinoma and urothelial carcinoma of the renal pelvis in the same kidney is extremely rare, although previously reported. With this study we aim to present our case and provide a literature review on this entity.
methodsAn otherwise healthy 43-year-old military male with the chief complaint of left plank pain was seen in the office. Imaging revealed the presence of a 3.5 cm left renal mass. Left laparoscopic radical nephrectomy was performed for presumed renal malignancy. Pathology confirmed the presence of a clear cell RCC and revealed an area of low-grade UC arising from the ipsilateral renal pelvis, not visible in the preoperative imaging. Furthermore, a Pubmed database search in English language was conducted, up to June 2021, to identify the rate of simultaneous RCC and UC of the renal pelvis or ureter in RN specimen performed for presumed RCC or renal malignancy and subsequent management in these cases.
resultsA total of 53 articles reporting on 56 patients with synchronous ipsilateral RCC and UC of the renal pelvis were identified, together with our case. Eight cases (14%) were initially managed with RN, thereby requiring further management of the ureteral stump. Of these, six (75%) were managed with distal ureterectomy, one (12.5%) with active surveillance of the ureteral stump, while one case (12.5%) did not report subsequent management. To our knowledge, we present the youngest patient recorded in the literature, with this histology combination presenting synchronously in the same kidney.
conclusionsAlthough uncommon, the final pathology report may reveal neoplasms of dissimilar histology that may involve the renal pelvis. It is crucial for urologists and pathologists to be vigilant of such cases during a solid renal mass workup. Additional therapeutic adjustments may be necessitated, derailing the initial treatment plan.
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