ArticleAnnals of cardiac anaesthesia
Clinical outcomes of del nido cardioplegia and st thomas blood cardioplegia in neonatal congenital heart surgery.
Article in Annals of cardiac anaesthesia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Custodiol versus blood cardioplegia in pediatric cardiac surgery: a randomized controlled trial.European journal of medical research · 2023Trial
- Article
- Incidence and Factors Associated with Neurological Complications Following Pediatric Heart Surgery: A Retrospective Study.Journal of clinical medicine · 2026Article
- Myocardial Protection Efficacy of Custodiol, Del Nido, and Cold Intermittent Blood Cardioplegia in Arterial Switch Operation.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Revisiting risk factors and incidence of postoperative tachyarrhythmias in pediatric cardiac surgery.Scientific reports · 2025Article
- Comparison of Clinical Outcomes of Two Different Cardioplegic Solutions in Patients Undergoing Coronary Artery Bypass Graft Surgery; A randomize clinical trial.Advanced biomedical research · 2025Article
- Which is better for pediatric and adult cardiac surgery: del Nido or St. Thomas cardioplegia? A systematic review and meta-analysis.Indian journal of thoracic and cardiovascular surgery · 2023Article
- Cardioplegia in Open Heart Surgery: Age Matters.Journal of clinical medicine · 2023Review
- The outcome of surgery for congenital heart disease in India: A systematic review and metanalysis.Annals of pediatric cardiologyArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCardioplegia is essential for adequate myocardial protection. There continues to remain ambiguity regarding the ideal cardioplegia for adequate myocardial protection in congenital heart surgery. This study compares clinical outcomes using St Thomas II solution and Del Nido cardioplegia in neonates undergoing cardiac surgery.
methodsAll neonates (<30 days) from 2011 to 2017 who underwent surgery requiring cardioplegic arrest were analyzed retrospectively. We divided the cohort into two groups depending on cardioplegia received, as group A (Blood cardioplegia with St Thomas II solution, n = 56) and group B (Del Nido cardioplegia, n = 48). Various demographic, intraoperative, early postoperative, and discharge variables were analyzed.
resultsTwo groups were similar in age, gender, pre-operative diagnosis, and risk category. Cardiopulmonary bypass (CPB) time (P = 0.002), aortic cross-clamp (ACC) time (P = 0.018), and the number of doses of cardioplegia (P < 0.001) were significantly lower with Del Nido group. Though vasoactive inotropic score (VIS) (P = 0.036) was high during the first 24 h in the immediate postoperative period in group A, there was no difference in early mortality among both groups (P = 0.749). Both groups did not show significant differences related to various postoperative and discharge variables.
conclusionWhen compared to St. Thomas solution, the use of Del Nido cardioplegia solution in neonates is associated with a significant decrease in CPB and ACC times and VIS in the first 24 h after surgery. The choice of cardioplegia (St Thomas/Del Nido) in neonates does not affect early mortality and early postoperative clinical outcomes.
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