ArticleProceedings of the National Academy of Sciences of the United States of America2022
Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Evidence Synthesis of Gene Therapy and Gene Editing from Different Disorders-Implications for Individuals with Rett Syndrome: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Generalized Dystonia With Cervical Predominance in a Patient With a De Novo TCF20 Variant.Annals of clinical and translational neurology · 2026Article
- A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex.Science (New York, N.Y.) · 2026Article
- MECP2 Rare Variants in Boys With Central Precocious Puberty.The Journal of clinical endocrinology and metabolism · 2026Article
- Current insights into PHF14: molecular features and functional roles.Frontiers in molecular biosciences · 2026Review
- MeCP2 functions as a DNA methylation reader in immune homeostasis and cancer.Frontiers in epigenetics and epigenomics · 2026Review
- Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex.Cell genomics · 2025Article
- MeCP2 interacts with the super elongation complex to regulate transcription.Science advances · 2025Article
- A Boy with a Novel Variant inChildren (Basel, Switzerland) · 2025Article
- Immunomodulation of behavior impairment via spleen-specific targeting lipid nanoparticles in a MeCP2 transgenic mouse model.Scientific reports · 2025Article
- M2-exo promote orthodontic bone remodeling via the MeCP2-TCF20-HDAC1 axis.Stem cell research & therapy · 2025Article
- Exploring the complexity of MECP2 function in Rett syndrome.Nature reviews. Neuroscience · 2025Review
- Article
- Article
- Genome-wide association analysis of composite sleep health scores in 413,904 individuals.Communications biology · 2025Article
- Regulation of Dendrite and Dendritic Spine Formation by TCF20.Journal of neurochemistry · 2025Article
- Epigenetic Regulation and Neurodevelopmental Disorders: From MeCP2 to the TCF20/PHF14 Complex.Genes · 2024Review
- Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment.bioRxiv : the preprint server for biology · 2024Article
- Dystonic Cerebral Palsy-Like Presentation Caused by a Novel TCF20 Variant.Journal of movement disorders · 2024Article
- Evidence for common mechanisms of pathology between SHANK3 and other genes of Phelan-McDermid syndrome.Clinical genetics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 8 institutions in 3 countries.
Jian ZhouDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Hamdan HamdanDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030.
Hari Krishna YalamanchiliJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030.
Kaifang PangJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030.
Amy E PohodichJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030.
Joanna LopezDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Yingyao ShaoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Juan A Oses-PrietoDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Lifang LiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Wonho KimDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Mark A DurhamJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030.
Sameer S BajikarDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Donna J PalmerDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Philip NgDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Michelle L ThompsonHudsonAlpha Institute for Biotechnology, Huntsville, AL 35806.
E Martina BebinDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294.
Amelie J MüllerInstitute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen 72076, Germany.
Alma KuechlerInstitut für Humangenetik, Universitätsklinikum Essen, Essen 45147, Germany.
Antje KampmeierInstitut für Humangenetik, Universitätsklinikum Essen, Essen 45147, Germany.
Tobias B HaackInstitute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen 72076, Germany.
Alma L BurlingameDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.ORCID 0000-0002-8403-7307
Zhandong LiuJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030.
Matthew N RasbandDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030.
Huda Y ZoghbiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030; hzoghbi@bcm.edu.
Baylor College of Medicine · USEssen University Hospital · DEUniversity of California, San Francisco · USUniversity of Tübingen · DEAgricultural Research Service · USHudsonAlpha Institute for Biotechnology · USKhalifa University of Science and Technology · AEUniversity of Alabama at Birmingham · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MMOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROMER01NS057819 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ZOGHBI, HUDA Y · 2006 to 2025
$7.5MThe Molecular Architecture of Axons in Health and DiseaseR35NS122073 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI MATTHEW N RASBAND · 2021 to 2026
$5.6MImaging Mass Spectrometry for metabolome mappingR01GM120033 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI LIU, ZHANDONG, MALETIC-SAVATIC, MIRJANA · 2017 to 2021
$2.5MHigh Throughput Genomic Sequencer at BCM Core FacilityS10OD023469 · OD · BAYLOR COLLEGE OF MEDICINE · PI CHEN, RUI · 2017 to 2017
$600kInvestigating the role of Growth-differentiation factor 11 in neurodevelopmental and MECP2-related disordersF32HD100048 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI BAJIKAR, SAMEER · 2019 to 2021
$168kHoward Hughes Medical InstituteNCI NIH HHS P30 CA125123NICHD NIH HHS F32 HD100048NICHD NIH HHS P50 HD103555NIGMS NIH HHS R01 GM120033NIH HHS S10 OD023469NINDS NIH HHS R01 NS057819NINDS NIH HHS R35 NS122073Wellcome Trust
Abstract
MeCP2 is associated with Rett syndrome (RTT),
Indexed as
AllelesAnimalsBiomarkersBrainDisease Models, AnimalDisease SusceptibilityMethyl-CpG-Binding Protein 2MiceMice, KnockoutMice, TransgenicModels, BiologicalMultiprotein ComplexesMutationNeurodevelopmental DisordersNeuronsNuclear ProteinsBiomarkersMecp2 protein, mouseMethyl-CpG-Binding Protein 2Multiprotein ComplexesNuclear ProteinsPHF14 protein, humanTcf20 protein, mouseTranscription FactorsBioIDMeCP2neurodevelopmental disordersRett syndromeTCF20 complex
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.