ArticleProceedings of the National Academy of Sciences of the United States of America2022
Conformation-driven strategy for resilient and functional protein materials.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Bioactive 3D-Printed valve scaffold promoting valvular regeneration via immunomodulation and endothelialization.Bioactive materials · 2026Article
- Water-state control unlocks durable and elastic silk fibroin hydrogels.Nature communications · 2026Article
- Ordered-Disorder Transition Induced Stretchable Collagen Ionic Gels Toward Flexible Sensors.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Engineering conformational transitions in silk fibroin hydrogels to create advanced dynamic microenvironments for biomedical applications.Regenerative biomaterials · 2026Review
- Silk Fibroin-Based Hydrogels Supplemented with Decellularized Extracellular Matrix and Gelatin Facilitate 3D Bioprinting for Meniscus Tissue Engineering.Macromolecular bioscience · 2025Article
- Probing the Interplay of Protein Self-Assembly and Covalent Bond Formation in Photo-Crosslinked Silk Fibroin Hydrogels.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Bovine Serum Albumin-Based Sponges as Biocompatible Adsorbents: Development, Characterization, and Perfluorooctane Sulfonate Removal Efficiency.Small science · 2025Article
- Order-Disorder Balance in Silk-Elastin-like Polypeptides Determines Their Self-Assembly into Hydrogel Networks.ACS applied materials & interfaces · 2025Article
- Gelatin-Based Polymers Can Be Processed to Highly Resilient Biocompatible Porous Hydrogel Scaffolds for Soft Tissue Regeneration Applications.Gels (Basel, Switzerland) · 2024Article
- Formulation Effects on the Mechano-Physical Properties of In Situ-Forming Resilient Hydrogels for Breast Tissue Regeneration.Journal of functional biomaterials · 2024Article
- Photo-/thermo-responsive bioink for improved printability in extrusion-based bioprinting.Materials today. Bio · 2024Article
- Building Blood Vessel Chips with Enhanced Physiological Relevance.Advanced materials technologies · 2023Article
- A brief review on the mechanisms and approaches of silk spinning-inspired biofabrication.Frontiers in bioengineering and biotechnology · 2023Review
- Preparation and Properties of Egg White Dual Cross-Linked Hydrogel with Potential Application for Bone Tissue Engineering.Polymers · 2022Article
- Acetic Acid Enables Precise Tailoring of the Mechanical Behavior of Protein-Based Hydrogels.Nano letters · 2022Article
- Down-Regulating Scar Formation by Microneedles DirectlyACS nano · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The exceptional elastic resilience of some protein materials underlies essential biomechanical functions with broad interest in biomedical fields. However, molecular design of elastic resilience is restricted to amino acid sequences of a handful of naturally occurring resilient proteins such as resilin and elastin. Here, we exploit non-resilin/elastin sequences that adopt kinetically stabilized, random coil-dominated conformations to achieve near-perfect resilience comparable with that of resilin and elastin. We also show a direct correlation between resilience and Raman-characterized protein conformations. Furthermore, we demonstrate that metastable conformation of proteins enables the construction of mechanically graded protein materials that exhibit spatially controlled conformations and resilience. These results offer insights into molecular mechanisms of protein elastomers and outline a general conformation-driven strategy for developing resilient and functional protein materials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.