ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Frequency Shapes the Quality of Tactile Percepts Evoked through Electrical Stimulation of the Nerves.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Mind the gap: the temporal discrimination threshold of tactile sensation from implanted peripheral nerve stimulation.Journal of neuroengineering and rehabilitation · 2026Trial
- A methodological framework for the efficient characterization of peripheral nerve stimulation parameters.Journal of neural engineering · 2025Trial
- A lightweight durable full-body electrical stimulation suit for haptic feedback and therapeutic applications.Nature communications · 2026Article
- Tactile-evoked EEG Dataset for Natural Perception Using an Integrated Stimulation-Recording Framework.Scientific data · 2025Article
- Enhanced sensory perception and myoelectric control with high channel count implanted sensorimotor systems.Journal of neural engineering · 2025Article
- Toward Natural Limb Function: A New Era in Prosthetic Innovation.Annals of neurology · 2025Review
- Advanced Brain-on-a-Chip for Wetware Computing: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Optimization frameworks for bespoke sensory encoding in neuroprosthetics.APL bioengineering · 2025Article
- Considerations for tactile perceptual assessments: impact of arm dominance, nerve, location, and sex in young and older adults.Experimental brain research · 2025Article
- The Next Frontier in Neuroprosthetics: Integration of Biomimetic Somatosensory Feedback.Biomimetics (Basel, Switzerland) · 2025Review
- Direct Prosthesis Force Control with Tactile Feedback May Connect with the Internal Model.medRxiv : the preprint server for health sciences · 2024Article
- The effects of neuron morphology and spatial distribution on the selectivity of dorsal root ganglion stimulation.Journal of neural engineering · 2024Article
- Clinical Applications and Future Translation of Somatosensory Neuroprostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- The neurophysiology of sensorimotor prosthetic control.BMC biomedical engineering · 2024Review
- Sensory integration for neuroprostheses: from functional benefits to neural correlates.Medical & biological engineering & computing · 2024Review
- Biophysics of Frequency-Dependent Variation in Paresthesia and Pain Relief during Spinal Cord Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation.Nature communications · 2024Article
- High-frequency amplitude-modulated sinusoidal stimulation induces desynchronized yet controllable neural firing.bioRxiv : the preprint server for biology · 2024Article
- Multiplexing intensity and frequency sensations for artificial touch by modulating temporal features of electrical pulse trains.Frontiers in neuroscience · 2024Article
- Characterization of perception by transcutaneous electrical Stimulation in terms of tingling intensity and temporal dynamics.Biomedical engineering letters · 2024Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Electrical stimulation of the peripheral nerves of human participants provides a unique opportunity to study the neural determinants of perceptual quality using a causal manipulation. A major challenge in the study of neural coding of touch has been to isolate the role of spike timing-at the scale of milliseconds or tens of milliseconds-in shaping the sensory experience. In the present study, we address this question by systematically varying the pulse frequency (PF) of electrical stimulation pulse trains delivered to the peripheral nerves of seven participants with upper and lower extremity limb loss via chronically implanted neural interfaces. We find that increases in PF lead to systematic increases in perceived frequency, up to ∼50 Hz, at which point further changes in PF have little to no impact on sensory quality. Above this transition frequency, ratings of perceived frequency level off, the ability to discriminate changes in PF is abolished, and verbal descriptors selected to characterize the sensation change abruptly. We conclude that sensation quality is shaped by temporal patterns of neural activation, even if these patterns are imposed on a fixed neural population, but this temporal patterning can only be resolved up to ∼50 Hz. These findings highlight the importance of spike timing in shaping the quality of a sensation and will contribute to the development of encoding strategies for conveying touch feedback through bionic hands and feet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.