Evidence map›Paper›PMID 35074551›Full record

ArticleJournal of inorganic biochemistry2022

Synthesis and characterization of a model complex for flavodiiron NO reductases that stabilizes a diiron mononitrosyl complex.

Hai T Dong, Yu Zong, Abigail J Bracken, Michael O Lengel, Jeff W Kampf, Debangsu Sil, Carsten Krebs, Nicolai Lehnert

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Synthesis and Structural Characterization of a Non-Heme Iron Hyponitrite Complex.Angewandte Chemie (International ed. in English) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hai T DongDepartment of Chemistry, The University of Michigan, Ann Arbor, MI 48109-1055, United States.
Yu ZongDepartment of Chemistry, The University of Michigan, Ann Arbor, MI 48109-1055, United States.
Abigail J BrackenDepartment of Chemistry, The University of Michigan, Ann Arbor, MI 48109-1055, United States.
Michael O LengelDepartment of Chemistry, The University of Michigan, Ann Arbor, MI 48109-1055, United States.
Jeff W KampfDepartment of Chemistry, The University of Michigan, Ann Arbor, MI 48109-1055, United States.
Debangsu SilDepartment of Chemistry, University Park, PA 16802, United States.
Carsten KrebsDepartment of Chemistry, University Park, PA 16802, United States; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, United States.
Nicolai LehnertDepartment of Chemistry, The University of Michigan, Ann Arbor, MI 48109-1055, United States. Electronic address: lehnertn@umich.edu.
University of Michigan–Ann Arbor · USPark University · USPennsylvania State University · US

Funding

Mechanisms of Mononuclear non-Heme-Iron EnzymesR35GM127079 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CARSTEN KREBS · 2018 to 2026
$3.8M
NIGMS NIH HHS R35 GM127079
6 · The paper itself

Abstract

Flavodiiron NO reductases (FNORs) are important enzymes in microbial pathogenesis, as they equip microbes with resistance to the human immune defense agent nitric oxide (NO). DFT calculations predict that a network of second coordination sphere (SCS) hydrogen bonds is critical for the key NN coupling step in the NO reduction reaction catalyzed by FNORs. In this study, we report the synthesis of a model complex of FNORs with pendant hydrogen bond donors. For this purpose, the ligand H[BPMP] (= 2,6-bis[[bis(2-pyridylmethyl)amino]methyl]-4-methylphenol) was modified with two amide groups in the SCS. Reaction of the precursor complex [Fe

Indexed as

CatalysisCoordination ComplexesHumansHydrogen BondingIronLigandsModels, ChemicalMolecular StructureNitric OxideOxidoreductasesCoordination ComplexesIronLigandsNitric Oxidenitric-oxide reductaseOxidoreductasesFlavodiiron proteinsiron-nitrosyl complexesModel complexesNitric oxide reductasesNon-heme diiron enzymesSecond coordination sphere effects

Identifiers

PMID35074551
PMCPMC8915779
OpenAlexW4206124804

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.