Evidence map›Paper›PMID 35074486›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2022

Frustration, Cognition, and Psychophysiology in Dysregulated Children: A Research Domain Criteria Approach.

Merelise R Ametti, Eileen T Crehan, Kerry O'Loughlin, Meghan C Schreck, Sarahjane L Dube, Alexandra S Potter, Stacey C Sigmon, Robert R Althoff

Abstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Exploring Transdiagnostic Mechanisms of Youth Externalizing Psychopathology: A Longitudinal Person-Centered Approach.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  4. Maternal Depressive Symptoms and Risk for Childhood Depression: Role of Executive Functions.Journal of the American Academy of Child and Adolescent Psychiatry · 2025
    Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Irritability in Youths: A Critical Integrative Review.The American journal of psychiatry · 2024
    Review
  12. A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice.Biological psychiatry global open science · 2024
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Merelise R AmettiUniversity of Vermont, Burlington.
Eileen T CrehanTufts University, Medford, Massachusetts.
Kerry O'LoughlinJudge Baker Children's Center, Boston, Massachusetts.
Meghan C SchreckMcLean Hospital, Harvard Medical School, Belmont, Massachusetts.
Sarahjane L DubeUniversity of Vermont, Burlington.
Alexandra S PotterUniversity of Vermont, Burlington.
Stacey C SigmonUniversity of Vermont, Burlington.
Robert R AlthoffUniversity of Vermont, Burlington. Electronic address: ralthoff@med.uvm.edu.

Funding

Vermont Center on Behavior and HealthP20GM103644 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SIGMON, STACEY C · 2013 to 2022
$21.3M
Child Behavior Checklist-Dysregulation Profile: Genes, Environment, & Life CourseK08MH082116 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ALTHOFF, ROBERT RUSSELL · 2009 to 2013
$950k
NIGMS NIH HHS P20 GM103644NIMH NIH HHS K08 MH082116
6 · The paper itself

Abstract

objectiveDysregulated children experience significant impairment in regulating their affect, behavior, and cognitions and are at risk for numerous adverse sequelae. The unclear phenomenology of their symptoms presents a barrier to evidence-based diagnosis and treatment.

methodThe cognitive, behavioral, and psychophysiological mechanisms of dysregulation were examined in a mixed clinical and community sample of 294 children ages 7-17 using the Research Domain Criteria constructs of cognitive control and frustrative nonreward.

resultsResults showed that caregivers of dysregulated children viewed them as having many more problems with everyday executive function than children with moderate or low levels of psychiatric symptoms; however, during standardized assessments of more complex cognitive control tasks, performance of dysregulated children differed only from children with low symptoms on tests of cognitive flexibility. In addition, when frustrated, dysregulated children performed more poorly on the Go/No-Go Task and demonstrated less autonomic flexibility as indexed by low respiratory sinus arrhythmia and pre-ejection period scores.

conclusionThe findings of this study suggest that autonomic inflexibility and impaired cognitive function in the context of frustration may be mechanisms underlying childhood dysregulation.

Indexed as

FrustrationRespiratory Sinus ArrhythmiaAdolescentChildCognitionExecutive FunctionHumansPsychophysiologycognitionemotion regulationfrustrationpsychophysiologyyouth

Identifiers

PMID35074486
PMCPMC9275749

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.