Evidence map›Paper›PMID 35074459›Full record

ArticleAppetite2022

Meal-to-meal and day-to-day macronutrient variation in an ad libitum vending food paradigm.

Tomás Cabeza de Baca, Paolo Piaggi, Marci E Gluck, Jonathan Krakoff, Susanne B Votruba

Abstract read
In one paragraph

Article in Appetite, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tomás Cabeza de BacaPhoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, Phoenix, AZ, USA. Electronic address: tommy.cabezadebaca@nih.gov.
Paolo PiaggiPhoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, Phoenix, AZ, USA.
Marci E GluckPhoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, Phoenix, AZ, USA.
Jonathan KrakoffPhoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, Phoenix, AZ, USA.
Susanne B VotrubaPhoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, Phoenix, AZ, USA.

Funding

Regulators of Food IntakeZIADK069091 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRAKOFF, JONATHAN · 2009 to 2025
$15.0M
Intramural NIH HHS Z99 DK999999
6 · The paper itself

Abstract

backgroundTheory posits that macronutrient intake is regulated by protein consumption and adequate intake of protein results in consumption of less carbohydrates and fat. The current study investigates the effect of protein intake on calorie and macronutrient content using an ad libitum vending machine paradigm.

methodsHealthy volunteers (n = 287; 177 m; Age = 36 ± 11; BMI = 32 ± 8) were admitted to our clinical research unit. Macronutrient meal content (grams) and energy intake (Kcal) were quantified by specialized food processing software and collected on an hourly basis over a three-day period using a validated ad libitum vending machine paradigm. Body composition was assessed by DXA. Lagged multi-level models accounting for age, sex, race/ethnicity, fat and fat free mass indices were fitted to examine the impact of prior macronutrient content on subsequent meals.

resultsProtein intake was associated with decreased energy intake (Kcal; B = -1.67 kcal, p = 0.0048), lower protein and carbohydrate intake (B = -0.08 g, p = 0.0006; B = -0.21 g, p = 0.0003, respectively) at subsequent meals. Daily Macronutrient intake and subsequent intake were positively associated.

conclusionsDietary protein exhibits a negative regulatory effect on a short-term meal-to-meal rather than day-to-day basis. In the setting of readily available food, protein intake impacts energy intake only over very short time courses.

Indexed as

Dietary CarbohydratesDietary FatsAdultEnergy IntakeHumansMealsMiddle AgedNutrientsDietary CarbohydratesDietary FatsNutrientsAd libitumCaloriesFood intakeMacronutrient contentMacronutrient regulationVending machine

Identifiers

PMID35074459
PMCPMC8842501

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.