ArticleEnvironmental research2022
Cigarette smoking is associated with acrylamide exposure among the U.S. population: NHANES 2011-2016.
Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Volatile Organic Compound Metabolites Are Found in the Urine of Breastfed Infants Whose Mothers Use Cannabis: The Lactation and Cannabis (LAC) Study.International journal of environmental research and public health · 2026Article
- Lung microbiome predictors of epigenetic aging and potential associations with smoking and electronic cigarette use.Clinical epigenetics · 2026Article
- Acrylamide Exposure Exacerbates Type 2 Diabetes-Induced Neurotoxicity: An Integrated Neurobehavioral and Molecular Investigation.Life (Basel, Switzerland) · 2026Article
- Relationship of Urinary Mercapturic Acids of Selected Tobacco Smoke Constituents to Chronic Obstructive Pulmonary Disease in Cigarette Smokers of the Singapore Chinese Health Study.Chemical research in toxicology · 2026Article
- Nonlinear association of HbA1c/HDL-C ratio with heart failure in adults: a large cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Zebrafish as a Model Organism to Study Neurotoxicity: A Potential Tool for Neuroprotective Drug Discovery.Current drug metabolism · 2026Review
- Dietary zinc intake and 10-year atherosclerotic cardiovascular disease risk in diabetes mellitus patients: evidence from NHANES database.Thrombosis journal · 2025Article
- Associations between internal exposure to acrylamide and sleep health: evidence from NHANES 2013-2016.BMC public health · 2025Article
- Dietary sodium intake and all-cause mortality in rheumatoid arthritis: an NHANES analysis (2003-2018).Frontiers in nutrition · 2025Article
- Association of acrylamide exposure with markers of systemic inflammation and serum alpha-klotho concentrations in middle-late adulthood.Frontiers in public health · 2025Article
- Association Between Dietary Antioxidant Quality Score (DAQS) and All-Cause Mortality in Hypertensive Adults: A Retrospective Cohort Study from the NHANES Database.Biological trace element research · 2024Article
- Detoxification of Acrylamide by Potentially Probiotic Strains of Lactic Acid Bacteria and Yeast.Molecules (Basel, Switzerland) · 2024Article
- Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database.Journal of health, population, and nutrition · 2024Article
- Assessing the Influence of Intermittent Alcohol Access on Acrylamide-Induced Neuronal Toxicity in an Experimental Rat Model.Brain sciences · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
2-carbamoylethyl mercapturic acid (2CaEMA, N-Acetyl-S-carbamoylethyl-L-cysteine) is a urinary metabolite and exposure biomarker of acrylamide, which is a harmful volatile organic compound found in cigarette smoke and in some foods. The goal of this study was to determine the association between cigarette smoking and urinary 2CaEMA concentrations among the U.S. population while considering potential dietary sources of acrylamide intake and demographics. We measured 2CaEMA concentrations in urine specimens collected during the National Health and Nutrition Examination Survey 2011-2012, 2013-2014, and 2015-2016 cycles from eligible participants 18 years and older (n = 5443) using liquid chromatography/tandem mass spectrometry. We developed multiple regression models with urinary 2CaEMA concentrations as the dependent variable and sex, age, race/Hispanic origin, reported primary sources of dietary acrylamide intake, and cigarette smoke exposure as independent variables. This study demonstrates that cigarette smoking is strongly associated with urinary 2CaEMA, suggests that cigarette smoking is likely a primary source of acrylamide exposure, and provides a baseline measure for 2CaEMA in the U.S. population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.