Evidence map›Paper›PMID 35074166›Full record

ArticleDental materials : official publication of the Academy of Dental Materials2022

Three-dimensional printing of clinical scale and personalized calcium phosphate scaffolds for alveolar bone reconstruction.

Margaret Anderson, Nileshkumar Dubey, Kath Bogie, Chen Cao, Junying Li, Joseph Lerchbacker, Gustavo Mendonça, Frederic Kauffmann, Marco C Bottino, Darnell Kaigler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dental materials : official publication of the Academy of Dental Materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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  13. Biofabrication - Revolutionizing the future of regenerative periodontics.Dental materials : official publication of the Academy of Dental Materials · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Margaret AndersonDepartment of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Nileshkumar DubeyDepartment of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA; Faculty of Dentistry, National University of Singapore, Singapore.
Kath BogieCase Western Reserve University, Cleveland, OH, USA.
Chen CaoDepartment of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Junying LiDepartment of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Joseph LerchbackerCase Western Reserve University, Cleveland, OH, USA.
Gustavo MendonçaDepartment of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Frederic KauffmannDepartment of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Marco C BottinoDepartment of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA.
Darnell KaiglerDepartment of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: dkaigler@umich.edu.
University of Michigan–Ann Arbor · USCase Western Reserve University · USNational University of Singapore · SG

Funding

Redefining mesenchymal stem cells: using their cellular and molecular phenotypes to determine their regenerative and therapeutic propertiesR01DE028657 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAIGLER, DARNELL · 2019 to 2023
$2.1M
Combined bioprinting with stem cell technology to regenerate skin burn woundsR01GM143938 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOTTINO, MARCO C, CASTILHO, ROGERIO MORAES · 2021 to 2024
$2.0M
NOVEL THERAPEUTICS TO TREAT NECROTIC TEETH: THE COMBINATORIAL EFFECT OF A 3D DRUG DELIVERY SYSTEM AND SPATIALLY DESIGNED STEM CELL NICHESR01DE026578 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOTTINO, MARCO C · 2017 to 2021
$1.7M
Customized craniofacial stem cell therapy for craniofacial bone defectsR56DE025097 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAIGLER, DARNELL · 2015 to 2016
$739k
A Novel Multilayered Membrane for Periodontal RegenerationK08DE023552 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOTTINO, MARCO C · 2013 to 2017
$716k
Biomodification of Dentin Matrix StructureR56DE021040 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BEDRAN-RUSSO, ANA KARINA B · 2017 to 2017
$648k
NIDCR NIH HHS K08 DE023552NIDCR NIH HHS R01 DE026578NIDCR NIH HHS R01 DE028657NIDCR NIH HHS R56 DE021040NIDCR NIH HHS R56 DE025097NIGMS NIH HHS R01 GM143938
6 · The paper itself

Abstract

objectiveAlveolar bone defects can be highly variable in their morphology and, as the defect size increases, they become more challenging to treat with currently available therapeutics and biomaterials. This investigation sought to devise a protocol for fabricating customized clinical scale and patient-specific, bioceramic scaffolds for reconstruction of large alveolar bone defects.

methodsTwo types of calcium phosphate (CaP)-based bioceramic scaffolds (alginate/β-TCP and hydroxyapatite/α-TCP, hereafter referred to as hybrid CaP and Osteoink™, respectively) were designed, 3D printed, and their biocompatibility with alveolar bone marrow stem cells and mechanical properties were determined. Following scaffold optimization, a workflow was developed to use cone beam computed tomographic (CBCT) imaging to design and 3D print, defect-specific bioceramic scaffolds for clinical-scale bone defects.

resultsOsteoink™ scaffolds had the highest compressive strength when compared to hybrid CaP with different infill orientation. In cell culture medium, hybrid CaP degradation resulted in decreased pH (6.3) and toxicity to stem cells; however, OsteoInk™ scaffolds maintained a stable pH (7.2) in culture and passed the ISO standard for cytotoxicity. Finally, a clinically feasible laboratory workflow was developed and evaluated using CBCT imaging to engineer customized and defect-specific CaP scaffolds using OsteoInk™. It was determined that printed scaffolds had a high degree of accuracy to fit the respective clinical defects for which they were designed (0.27 mm morphological deviation of printed scaffolds from digital design). SIGNIFICANCE: From patient to patient, large alveolar bone defects are difficult to treat due to high variability in their complex morphologies and architecture. Our findings shows that Osteoink™ is a biocompatible material for 3D printing of clinically acceptable, patient-specific scaffolds with precision-fit for use in alveolar bone reconstructive procedures. Collectively, emerging digital technologies including CBCT imaging, 3D surgical planning, and (bio)printing can be integrated to address this unmet clinical challenge.

Indexed as

Printing, Three-DimensionalTissue ScaffoldsBiocompatible MaterialsBone RegenerationCalcium PhosphatesDurapatiteHumansTissue EngineeringBiocompatible MaterialsCalcium PhosphatesDurapatite3D printingBone reconstructionCalcium phosphateDigital planningScaffoldsStem cells

Identifiers

PMID35074166
PMCPMC9016367
OpenAlexW4206902603

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.