ArticleDevelopment and psychopathology2022
Impact of dimensions of early adversity on adult health and functioning: A 2-decade, longitudinal study.
Article in Development and psychopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Trajectories of internalizing problems during and after the COVID-19 pandemic: The effects of sex and early life stress.Journal of affective disorders · 2026Article
- Adverse Childhood Experiences and Life Course Depressive Symptoms: Do Peer Network Ties Buffer or Amplify?Society and mental health · 2026Article
- Anhedonia buffers the effects of early-life unpredictability on threat-reward decision-making.bioRxiv : the preprint server for biology · 2026Article
- Adverse childhood and adult experiences, intrinsic capacity decline, and subsequent physical-psychological-cognitive multimorbidity: a prospective cohort study from China.The journal of nutrition, health & aging · 2026Article
- Hearing and early life adversity: effects of developmental stress on sensory processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Mapping Dysregulation: Prenatal Predictors and Developmental Trajectories of Multiple Regulatory Problems in Early Childhood.Research on child and adolescent psychopathology · 2025Article
- Nucleus accumbens volume mediates the association between prenatal adversity and attention problems in youth.Development and psychopathology · 2025Article
- Adaptation and validation of the Chinese versions of the childhood perceived poverty and wealth questionnaire(C‑CPPWQ) and the childhood perceived unpredictability questionnaire (C‑CPUQ).BMC psychology · 2025Article
- Distinct roles of early life deprivation and unpredictability in shaping mating-related behaviours and sexual harassment perceptions.Frontiers in psychology · 2025Article
- Integration of positive environmental factors and differentiation of parental figures in social exposome research.Frontiers in psychology · 2025Article
- The association between childhood adversity and hippocampal volumes is moderated by romantic relationship experiences.The European journal of neuroscience · 2025Article
- Testing a Conceptual Model of Early Adversity, Neural Function, and Psychopathology: Protocol for a Retrospective Observational Cohort Study.JMIR research protocols · 2024Observational
- The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Individual longitudinal changes in DNA-methylome identify signatures of early-life adversity and correlate with later outcome.Neurobiology of stress · 2024Article
- Social support mediates the effects of childhood unpredictability on anhedonia: A retrospective investigation in an online adult community sample.Journal of mood and anxiety disorders · 2024Article
- Intergenerational Effects of a Family Cash Transfer on the Home Environment.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Associations Between Configurations of Childhood Adversity and Adult Mental Health Disorder Outcomes.Society and mental health · 2024Article
- Within-subject changes in methylome profile identify individual signatures of early-life adversity, with a potential to predict neuropsychiatric outcome.bioRxiv : the preprint server for biology · 2023Article
- Associations Between Early Life Adversity and Youth Psychobiological Outcomes: Dimensional and Person-Centered Approaches.Research on child and adolescent psychopathology · 2023Article
- Longitudinal effects of early psychosocial deprivation on macaque executive function: Evidence from computational modelling.Proceedings. Biological sciences · 2023Article
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3 authors.
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Abstract
Recent neurodevelopmental and evolutionary theories offer strong theoretical rationales and some empirical evidence to support the importance of specific dimensions of early adversity. However, studies have often been limited by omission of other adversity dimensions, singular outcomes, and short follow up durations. 1,420 participants in the community, Great Smoky Mountains Study, were assessed up to eight times between age 9 and 16 for four dimensions of early adversity: Threat, Material Deprivation, Unpredictability, and Loss (as well as a Cumulative Adversity measure). Participants were followed up to four times in adulthood (ages 19, 21, 25, and 30) to measure psychiatric disorders, substance disorder, and "real-world" functioning. Every childhood adversity dimension was associated with multiple adult psychiatric, substance, or functional outcomes when tested simultaneously in a multivariable analysis that accounted for other childhood adversities. There was evidence of differential impact of dimensions of adversity exposure on proximal outcomes (e.g., material deprivation and IQ) and even on distal outcomes (e.g., threat and emotional functioning). There were similar levels of prediction between the best set of individual adversity scales and a single cumulative adversity measure when considering distal outcomes. All dimensions of childhood adversity have lasting, pleiotropic effects, on adult health and functioning, but these dimensions may act via distinct proximal pathways.
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