Evidence map›Paper›PMID 35073927›Full record

ArticleJournal of neuroinflammation2022

Nos2

Xuan Ying Poh, Jia Mei Hong, Chen Bai, Qing Hao Miow, Pei Min Thong, Yu Wang, Ravisankar Rajarethinam, Cristine S L Ding, Catherine W M Ong

Erratum issued Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06446245 (DIRECT), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06446245 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

DIRECT: Doxycycline Adjunctive Therapy to Reduce Excess Mortality and Complications From Central Nervous System Tuberculosis - Phase II Randomized Clinical Trial

TypeinterventionalSponsorNational University Hospital, SingaporeRan2025 to 2027Enrolled200ConditionsTuberculosis, Meningeal, Tuberculosis, Meningitis (Etiology), Tuberculosis, Central Nervous SystemArmsDoxycycline, Placebo, Anti Tuberculosis Drug, Adjunctive corticosteroid
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Correction to: Nos2Journal of neuroinflammation · 2022
    Article
  4. Article
  5. Tuberculosis: The success tale of less explored dormantFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Xuan Ying PohInfectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 10th floor, Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Jia Mei HongInfectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 10th floor, Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Chen BaiInfectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 10th floor, Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Qing Hao MiowInfectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 10th floor, Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Pei Min ThongInfectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 10th floor, Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Yu WangInfectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 10th floor, Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Ravisankar RajarethinamAdvanced Molecular Pathology Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Cristine S L DingDepartment of Pathology, Tan Tock Seng Hospital, Singapore, Singapore.
Catherine W M OngInfectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 10th floor, Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore. Catherine_wm_ong@nuhs.edu.sg.
National University of Singapore · SGAgency for Science, Technology and Research · SGNational University Hospital · SGTan Tock Seng Hospital · SG

Funding

National University Health System NUHSRO/2016/066/NPCseedfunding/01National University of Singapore NUHSRO/2018/052/PDF/04National University of Singapore Research ScholarshipSingapore National Medical Research Council NMRC/CG/M009/2017_NUH/NUHSSingapore National Medical Research Council NMRC/TA/0042/2015
6 · The paper itself

Abstract

backgroundUnderstanding the pathophysiology of central nervous system tuberculosis (CNS-TB) is hampered by the lack of a good pre-clinical model that mirrors the human CNS-TB infection. We developed a murine CNS-TB model that demonstrates neurobehavioral changes with similar immunopathology with human CNS-TB.

methodsWe injected two Mycobacterium tuberculosis (M.tb) strains, H37Rv and CDC1551, respectively, into two mouse strains, C3HeB/FeJ and Nos2

resultsIntra-cerebroventricular infection of Nos2

conclusionsIntra-cerebroventricular infection of Nos2

Indexed as

Mycobacterium tuberculosisTuberculosisTuberculosis, Central Nervous SystemAnimalsDisease Models, AnimalHumansMiceMice, Inbred StrainsNitric Oxide Synthase Type IINitric Oxide Synthase Type IINOS2 protein, humanNos2 protein, mouseCNS-TBH37RvIntra-cerebroventricularMouse modelPyogranulomas

Identifiers

PMID35073927
PMCPMC8787888
OpenAlexW4207077553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.