ArticleJournal of biomedical science2022
Genomic diversity and antimicrobial resistance of Campylobacter spp. from humans and livestock in Nigeria.
Article in Journal of biomedical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The Impact ofInternational journal of environmental research and public health · 2024Pooled it
- Molecular epidemiology and genetic relatedness of zoonotic Campylobacter species from human and food-producing animal sources in Enugu State, Nigeria.Scientific reports · 2025Article
- Fecal carriage and multidrug resistance profiles of zoonoticVeterinary world · 2025Article
- Prevalence and Antimicrobial-Resistant Campylobacter jejuni and Campylobacter coli in Free-Range Chickens in Northwest Ethiopia.The American journal of tropical medicine and hygiene · 2025Article
- Livestock Antibiotics Use and Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2025Review
- Genome Analysis of the Multidrug-ResistantMicroorganisms · 2025Article
- Systematic review and meta-analysis ofOne health (Amsterdam, Netherlands) · 2025Review
- Article
- Genomic diversity of Campylobacter jejuni and Campylobacter coli isolated from the Ethiopian dairy supply chain.PloS one · 2024Article
- Occurrence and diversity of Campylobacter species in diarrheic children and their exposure environments in Ethiopia.PLOS global public health · 2024Article
- Whole-Genome Sequencing-Based Profiling of Antimicrobial Resistance Genes and Core-Genome Multilocus Sequence Typing ofInternational journal of molecular sciences · 2023Article
- In silico prediction and expression analysis of vaccine candidate genes of Campylobacter jejuni.Poultry science · 2023Article
- Occurrence of Diarrheagenic Pathogens and Their Coinfection Profiles in Diarrheic Under Five Children and Tracked Human Contacts in Urban and Rural Settings of Eastern Ethiopia.Microbiology insights · 2023Article
- Prevalence, antimicrobial resistance, virulence gene profile and molecular typing of Campylobacter species isolated from poultry meat samples.Veterinary medicine and science · 2022Article
- Antibiotic resistant bacteria: A bibliometric review of literature.Frontiers in public health · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCampylobacter spp. are zoonotic pathogens, ubiquitous and are found naturally as commensals in livestock from where they can be transmitted to humans directly or through animal products. The genomic diversity and antimicrobial resistance profile of Campylobacter was investigated with a focus on C. jejuni and C. coli in humans and livestock (poultry and cattle) from Nigeria.
methods586 human stool samples and 472 faecal samples from livestock were cultured for thermophilic Campylobacter species on modified charcoal cefoperazone deoxycholate agar (mCCDA). Culture in combination with whole genome sequencing identified and confirmed the presence of Campylobacter in humans and animals from the study area. Further analysis of the sequences was performed to determine multilocus sequence types and genetic determinants of antimicrobial resistance to fluoroquinolone, betalactam, tetracycline and macrolide classes of antimicrobials.
resultsFrom the human stool samples tested, 50 (9%) were positive of which 33 (66%) were C. jejuni, 14 (28%) were C. coli while 3 (6%) were C. hyointestinalis. In livestock, 132 (28%) were positive. Thirty one (7%) were C. jejuni while 101 (21%) were C. coli. Whole genome sequencing and MLST of the isolates revealed a total of 32 sequence types (STs) identified from 47 human isolates while 48 STs were identified in 124 isolates from livestock indicating a population which was overall, genetically diverse with a few more dominant strains. The antimicrobial resistance profiles of the isolates indicated a higher prevalence of resistance in Campylobacter isolated from livestock than in humans. Generally, resistance was greatest for betalactams (42%) closely followed by fluoroquinolones (41%), tetracyclines (15%) and lastly macrolides (2%). Multidrug resistance to three or more antimicrobials was observed in 24 (13%) isolates from humans (n = 1, 4%) and chicken (n = 23, 96%).
conclusionsThis study has further contributed information about the epidemiology, genetic diversity and antimicrobial resistance profile of thermophilic Campylobacter in Nigeria.
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