Evidence map›Paper›PMID 35073734›Full record

ArticlemBio2022

Global Regulatory Pathways Converge To Control Expression of Pseudomonas aeruginosa Type IV Pili.

Kimberly A Coggan, Matthew G Higgs, Evan D Brutinel, Jeremiah N Marden, Peter J Intile, Hanne C Winther-Larsen, Michael Koomey, Timothy L Yahr, Matthew C Wolfgang

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Role of cell-associated and secretion-independent virulence factors of Pseudomonas aeruginosa in microbial keratitis and anti-virulence therapeutic strategies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  3. Article
  4. Review
  5. Defining the role ofJournal of bacteriology · 2026
    Article
  6. Type IV pilin regulation: a transcriptional overview.Critical reviews in microbiology · 2026
    Review
  7. Separation ofmBio · 2025
    Article
  8. Article
  9. Article
  10. FTY720 Reduces the Biomass of Biofilms inAntibiotics (Basel, Switzerland) · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Kimberly A CogganDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Matthew G HiggsDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0002-5460-4980
Evan D BrutinelDepartment of Microbiology and Immunology, University of Iowagrid.214572.7, Iowa City, Iowa, USA.
Jeremiah N MardenMarsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA.
Peter J IntileDepartment of Microbiology and Immunology, University of Iowagrid.214572.7, Iowa City, Iowa, USA.
Hanne C Winther-LarsenCenter for Integrative Microbial Evolution and Department of Pharmacology and Pharmaceutical Biosciences, University of Oslogrid.5510.1, Oslo, Norway.
Michael KoomeyDepartment of Biosciences, Section for Genetics and Evolutionary Biology and Centre for Ecological and Evolutionary Synthesis, University of Oslogrid.5510.1, Oslo, Norway.
Timothy L YahrDepartment of Microbiology and Immunology, University of Iowagrid.214572.7, Iowa City, Iowa, USA.ORCID 0000-0001-9054-8704
Matthew C WolfgangDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · USUniversity of Iowa · USUniversity of Oslo · NO

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
Regulation of Pseudomonas aeruginosa type III secretionR01AI055042 · NIAID · UNIVERSITY OF IOWA · PI YAHR, TIMOTHY L · 2003 to 2021
$4.4M
Post-transcriptional regulation of Pseudomonas virulence gene expressionR01AI097264 · NIAID · UNIVERSITY OF IOWA · PI WOLFGANG, MATTHEW C, YAHR, TIMOTHY L · 2013 to 2016
$1.5M
Cyclic AMP Signaling in Pseudomonas aeruginosa VirulenceR01AI069116 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOLFGANG, MATTHEW C · 2008 to 2011
$1.3M
Regulation of Pseudomonas aeruginosa type III secretionR56AI055042 · NIAID · UNIVERSITY OF IOWA · PI YAHR, TIMOTHY L · 2016 to 2016
$339k
NIAID NIH HHS R01 AI055042NIAID NIH HHS R01 AI069116NIAID NIH HHS R01 AI097264NIAID NIH HHS R56 AI055042NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

The opportunistic pathogen Pseudomonas aeruginosa relies upon type IV pili (Tfp) for host colonization and virulence. Tfp are retractile surface appendages that promote adherence to host tissue and mediate twitching motility, a form of surface-associated translocation. Tfp are composed of a major structural pilin protein (PilA), several less abundant, fiber-associated pilin-like proteins (FimU, PilV, PilW, PilX, and PilE), and a pilus-associated tip adhesin and surface sensor (PilY1). Several proteins critical for Tfp biogenesis and surface sensing are encoded by the

Indexed as

Fimbriae ProteinsPseudomonas aeruginosaBacterial ProteinsFimbriae, BacterialVirulence FactorsBacterial ProteinsFimbriae ProteinsVirulence FactorsAlgRcAMPPseudomonas aeruginosatype IV piliVfr

Identifiers

PMID35073734
PMCPMC8787478
OpenAlexW4210439771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.