ArticleAnnals of pediatric endocrinology & metabolism2022
Single Point Insulin Sensitivity Estimator for predicting type 2 diabetes mellitus in obese adolescents.
Article in Annals of pediatric endocrinology & metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 16 citations in OpenAlex.
- Association of the single-point insulin sensitivity estimator (SPISE) index and incident cardiovascular disease in early-stage CKM syndrome: insights from the UK biobank.Diabetology & metabolic syndrome · 2026Article
- Association of the single point insulin sensitivity estimator index with functional outcomes and hemorrhagic transformation in patients with acute ischemic stroke.Frontiers in nutrition · 2026Article
- Single point insulin sensitivity estimator index is associated with predominance of atherogenic small, dense low-density lipoprotein cholesterol particles in Korean obese adults: a retrospective study.Korean journal of family medicine · 2026Article
- Comparison of SPISE and METS-IR and Other Markers to Predict Insulin Resistance and Elevated Liver Transaminases in Children and Adolescents.Diabetes & metabolism journal · 2025Article
- Comparison of single-point insulin sensitivity estimator (SPISE) index and cognitive performance in vitamin BJournal of family medicine and primary care · 2024Article
- Prediction of insulin resistance and elevated liver transaminases using serum uric acid and derived markers in children and adolescents.European journal of clinical nutrition · 2024Article
- The single point insulin sensitivity estimator (SPISE) is associated with bone health in Arab adults.Aging clinical and experimental research · 2024Article
- SPISE INDEX (Single point insulin sensitivity estimator): indicator of insulin resistance in children and adolescents with overweight and obesity.Frontiers in endocrinology · 2024Article
- Glycemic control and complications of type 2 diabetes mellitus in children and adolescents during the COVID-19 outbreak.Annals of pediatric endocrinology & metabolism · 2023Article
- Commentary on "Effects of once-weekly dulaglutide on juvenile type 2 diabetes mellitus and obesity in Korea: a pilot study".Annals of pediatric endocrinology & metabolism · 2023Article
- Sex-Specific Cut-Offs of Single Point Insulin Sensitivity Estimator (SPISE) in Predicting Metabolic Syndrome in the Arab Adolescents.Diagnostics (Basel, Switzerland) · 2023Article
- A Single-Point Insulin Sensitivity Estimator (SPISE) of 5.4 is a good predictor of both metabolic syndrome and insulin resistance in adolescents with obesity.Frontiers in endocrinology · 2023Article
- Commentary on "Single point insulin sensitivity estimator for predicting type 2 diabetes mellitus in obese adolescents".Annals of pediatric endocrinology & metabolism · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe prevalence of adolescents with type 2 diabetes mellitus (T2DM) has rapidly increased in Korea over the past few decades with the increase in the number of obese adolescents. The single point insulin sensitivity estimator (SPISE) was recently introduced as a surrogate marker for insulin sensitivity to predict T2DM in adults. We aimed to determine risk factors for T2DM in obese adolescents, including SPISE.
methodsThis retrospective study included 104 adolescents diagnosed with T2DM at Korea University Hospital between January 2010 and December 2020. We compared clinical and biochemical parameters and the SPISE of normoglycemic overweight and obese individuals with those of prediabetic and diabetic adolescents to determine risk factors for T2DM. Receiver operating characteristic analysis was performed with the Youden index to determine the cutoff point of SPISE.
resultsFrequency of fatty liver and family history of T2DM were significantly higher and SPISE level was significantly lower in patients with T2DM than in normoglycemic overweight/obese and prediabetic adolescents (p<0.01). A family history of T2DM, fatty liver, and SPISE value below the cutoff point (4.49) were identified as significant risk factors for T2DM in multiple logistic regression analysis after controlling for age, sex, and body mass index standard deviation score (p<0.01).
conclusionFamily history of T2DM, fatty liver, and low SPISE (<4.49) are risk factors that can independently affect the occurrence of T2DM in obese adolescents. Among these risk factors, SPISE is a promising marker for predicting adolescent T2DM; careful monitoring of these individuals is needed to prevent progression to T2DM.
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