ArticleNature2022
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM.
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In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 530 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
530citing papers in PubMed, 4 pooled it
64.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
530 citing papers in PubMed, 4 syntheses or guidelines pooled it, 802 citations in OpenAlex.
- Sero-epidemiological studies of pathogen burden: A scoping review.Wellcome open research · 2026Pooled it
- The Elusive B Cell Antigen in Multiple Sclerosis: Time to Rethink CNS B Cell Functions.International journal of molecular sciences · 2025Pooled it
- Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus.Nature communications · 2025Pooled it
- Repurposing Licensed Drugs with Activity Against Epstein-Barr Virus for Treatment of Multiple Sclerosis: A Systematic Approach.CNS drugs · 2025Pooled it
- Autologous Hematopoietic Transplantation Reduces Brain Inflammatory and Axoglial Damage Biomarkers in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2026Trial
- A scientific journey through viral immunology, vaccines, and neuroinflammation.Human vaccines & immunotherapeutics · 2026Article
- Multiple Sclerosis and Viruses: « Liaisons Dangereuses ».Reviews in medical virology · 2026Review
- EBNA1Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- The Impact of Antigen Presentation on BBB Disruption and Neuroinflammation.Physiology (Bethesda, Md.) · 2026Review
- Reframing the Gut-Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases.Annals of neurology · 2026Review
- Viral subversion of B-cell tolerance: mechanisms linking infection to autoimmunity.EMBO reports · 2026Review
- The Gut-Brain Axis and Neurodegenerative Diseases: From Mechanistic Pathways to Therapeutic Interventions.Probiotics and antimicrobial proteins · 2026Review
- Optimizing the Use of Anti-CD20 Agents in Multiple Sclerosis and Other Autoimmune Central Nervous System Disorders: A Narrative Review.Neurology and therapy · 2026Review
- Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases.MedComm · 2026Review
- Associations of viral infections and antiviral vaccinations with anti-NMDAR and other forms of autoimmune encephalitis.Brain, behavior, & immunity - health · 2026Review
- Epstein-Barr Virus: More than Just an Infection.Viruses · 2026Review
- EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse.Nature medicine · 2026Article
- IgA Deficiency Exacerbates an Animal Model of Multiple Sclerosis Induced with Theiler's Virus.Cells · 2026Article
- Interpreting Viral Associations in Neurodegenerative Diseases.International journal of molecular sciences · 2026Review
- Article
470 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 8 institutions in 3 countries.
Tobias V LanzDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7106-8801
R Camille BrewerDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0342-1826
Peggy P HoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Beckman Center for Molecular Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6848-318X
Jae-Seung MoonDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1983-465X
Kevin M JudeDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Beckman Center for Molecular Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3675-5136
Daniel FernandezMacromolecular Structure Knowledge Center, Stanford ChEM-H Institute, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6221-152X
Ricardo A FernandesDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Beckman Center for Molecular Medicine, Stanford, CA, USA.
Alejandro M GomezDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Gabriel-Stefan NadjDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Christopher M BartleyWeill Institute for Neurosciences, Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1391-4130
Ryan D SchubertWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Isobel A HawesWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Sara E VazquezDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Manasi IyerDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
J Bradley ZucheroDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Bianca TeegenInstitute of Experimental Immunology, Euroimmun AG, Lubeck, Germany.
Jeffrey E DunnDivision of Neuroimmunology, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Christopher B LockDivision of Neuroimmunology, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-4087-5894
Lucas B KippDivision of Neuroimmunology, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Victoria C CothamDepartment of Biochemistry and Molecular Pharmacology, NYU Perlmutter Cancer Center, NYU School of Medicine, New York, NY, USA.
Beatrix M UeberheideDepartment of Biochemistry and Molecular Pharmacology, NYU Perlmutter Cancer Center, NYU School of Medicine, New York, NY, USA.
Blake T AftabPreclinical Science and Translational Medicine, Atara Biotherapeutics, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-4020-2718
Mark S AndersonDepartment of Medicine, Diabetes Center, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3093-4758
Joseph L DeRisiDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Michael R WilsonWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8705-5084
Rachael J M Bashford-RogersWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-6838-0711
Michael PlattenDepartment of Neurology, Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-4746-887X
K Christopher GarciaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Beckman Center for Molecular Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9273-0278
Lawrence SteinmanDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Beckman Center for Molecular Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2437-2250
William H RobinsonDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. wrobins@stanford.edu.ORCID http://orcid.org/0000-0003-4385-704X
Stanford University · USUniversity of California, San Francisco · USVA Palo Alto Health Care System · USNYU Langone Health · USUniversity of Mannheim · DEAtara Biotherapeutics (United States) · USCentre for Human Genetics · GBEuroimmun Medizinische Labordiagnostika (Germany) · DE
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MA Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3MThe Role of B cells in the Origin and Progression of Multiple SclerosisR35NS111644 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEPHEN L HAUSER · 2019 to 2026
$9.1MUltra-Fast Epigenomic Maps for Monitoring AutoimmunityU19AI110491 · NIAID · STANFORD UNIVERSITY · PI MAECKER, HOLDEN T. · 2014 to 2018
$3.6MInvestigating Mucosal Breaks in the Initiation and Progression of Rheumatoid ArthritisR01AR078268 · NIAMS · STANFORD UNIVERSITY · PI ORANGE, DANA ELIZABETH, ROBINSON, WILLIAM H · 2021 to 2025
$3.1MLarge-Scale Characterization of Autoantibody Responses in Rheumatoid ArthritisR01AR063676 · NIAMS · STANFORD UNIVERSITY · PI ROBINSON, WILLIAM H · 2013 to 2017
$1.7MAcquisition of an Orbitrap Elite Mass Spectrometer with ETDS10OD010582 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI UEBERHEIDE, BEATRIX MAGDALENA · 2013 to 2013
$600kHoward Hughes Medical InstituteNIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI110491NIAMS NIH HHS R01 AR063676NIAMS NIH HHS R01 AR078268NIGMS NIH HHS P30 GM133894NIH HHS S10 OD010582NINDS NIH HHS R35 NS111644
Abstract
Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the cerebrospinal fluid (CSF) of patients with MS contribute to inflammation and secrete oligoclonal immunoglobulins
Indexed as
Epstein-Barr Virus InfectionsMultiple SclerosisAnimalsB-LymphocytesCell Adhesion Molecules, Neuron-GliaEpstein-Barr Virus Nuclear AntigensHerpesvirus 4, HumanHumansMiceNerve Tissue ProteinsCell Adhesion Molecules, Neuron-GliaEpstein-Barr Virus Nuclear AntigensGlialCAM protein, mouseNerve Tissue Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.