ArticleJournal of periodontology2022
Biome-microbiome interactions in peri-implantitis: A pilot investigation.
Article in Journal of periodontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- The Role of Biologically Active Materials in Peri-Implant Diseases.Journal of clinical medicine · 2026Review
- Comparison of microbiome profiles across sample types in patients with peri-implantitis using 16S rRNA sequencing.Journal of periodontal & implant science · 2026Article
- Impact of OMICS Technologies in Our Understanding of the Pathogenesis of Peri-Implantitis.Clinical and experimental dental research · 2026Review
- Integrative microbiome- and metatranscriptome-based analyses reveal diagnostic biomarkers for peri-implantitis.NPJ biofilms and microbiomes · 2025Article
- Epigenetic factors associated with peri-implantitis: a review.Journal of Zhejiang University. Science. B · 2025Review
- Cross-talk between NLRP3 and AIM2 inflammasomes in macrophage activation by LPS and titanium ions.Molecular medicine (Cambridge, Mass.) · 2025Article
- Microbial Dysbiosis, Titanium Release, and Peri-implantitis.Journal of dental research · 2025Review
- Community dynamics during de novo colonization of the nascent peri-implant sulcus.International journal of oral science · 2025Article
- A scoping review of diagnostic techniques used for the detection of peri-implantitis around endosseous dental implants.Frontiers in dental medicine · 2025Review
- Linking peri-implantitis to microbiome changes in affected implants, healthy implants, and saliva: a cross-sectional pilot study.Frontiers in cellular and infection microbiology · 2025Article
- NLRP3 and AIM2 inflammasomes expression is modified by LPS and titanium ions increasing the release of active IL-1β in alveolar bone-derived MSCs.Stem cells translational medicine · 2024Article
- Ultrastructural and immunohistochemical evaluation of hyperplastic soft tissues surrounding dental implants in fibular jaws.Scientific reports · 2024Article
- Impact of surface characteristics on the peri-implant microbiome in health and disease.Journal of periodontology · 2024Article
- Review
- Peri-implantitis Through the Looking Glass.International dental journal · 2024Article
- Correlation between Inflammasomes and Microbiota in Peri-Implantitis.International journal of molecular sciences · 2024Article
- Occlusive membranes for guided regeneration of inflamed tissue defects.Nature communications · 2023Article
- Difference in microbiome compositions of healthy peri-implant sulcus and peri-implantitis sulcus from the same patient.Heliyon · 2023Article
- The burden of diabetes on the soft tissue seal surrounding the dental implants.Frontiers in physiology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDental implants replace missing teeth in at least 100 million people, yet over one million implants fail every year due to peri-implantitis, a bacterially induced inflammatory disease. Our ability to treat peri-implantitis is hampered by a paucity of information on host-microbiome interactions that underlie the disease. Here, we present the first open-ended characterization of transcriptional events at the mucosal-microbial interface in the peri-implant crevice.
methodsWe simultaneously sequenced microbial and human mRNA from five pairs of healthy and diseased implants from the same patient and used graph theoretics to examine correlations between microbial and host gene expression in the peri-implant crevice.
resultsWe identified a transcriptionally active peri-implant microbiome surrounding healthy implants. Microbial genes encoding phenylalanine, tyrosine, and tryptophan biosynthesis, cysteine, methionine, arginine, proline, and histidine metabolism correlated to human genes encoding cell development, metabolism, morphogenesis, adhesion, gap junctions, cell-cell signaling, and immunoinflammatory pathways, suggesting a role for commensals in protecting epithelial integrity. In disease, we found 4- to 200-fold upregulation in microbial genes encoding biofilm thickness, heme transport and utilization, and Gram-negative cell membrane synthesis. These genes correlated with mucosal zinc finger proteins, apoptosis, membrane transport, inflammation, and cell-cell communication.
conclusionsWithin the limitations of a small sample size, our data suggest that microbial dysbiosis in the peri-implant sulcus might promote abandonment of host-bacterial transactions that dictate health and instead drive a move towards chronic programming of a non-healing wound.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.