ArticleAging2022
A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk.
Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- [Application of biological age for cardiovascular risk prediction in a community-based Chinese cohort].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi-Omics Integration.Aging cell · 2026Review
- From the lab to lifestyle: epigenetic clocks in personalized aging and health.Biogerontology · 2026Review
- Proteomic aging clocks in epidemiological studies: advances, applications and prospects.Nature aging · 2026Review
- Metabolomic signatures of extreme old age: findings from the New England Centenarian Study.GeroScience · 2026Article
- Comprehensive cross-sectional and longitudinal comparison of sixteen markers of biological aging from the Berlin Aging Study II.Communications medicine · 2026Article
- OMICmAge quantifies biological age by integrating multi-omics with electronic medical records.Nature aging · 2026Article
- Review
- Statistical modelling of an outcome variable with integrated multi-omics.BMC bioinformatics · 2025Article
- Patterns of Organ-Specific Proteomic Aging in Relation to Lifestyle, Diseases, and Mortality.Aging cell · 2025Article
- Reprogramming cellular senescence and aging clocks for advanced cancer immunotherapy.Molecular cancer · 2025Review
- A simple blood biomarker based on gene expression describes cardiovascular health-related biological age.GeroScience · 2025Article
- METABOLOMIC SIGNATURES OF EXTREME OLD AGE: FINDINGS FROM THE NEW ENGLAND CENTENARIAN STUDY.bioRxiv : the preprint server for biology · 2025Article
- How to measure and model cardiovascular aging.Cardiovascular research · 2025Review
- From ageing clocks to human digital twins in personalising healthcare through biological age analysis.NPJ digital medicine · 2025Article
- Exploring Epigenetic Ageing Using Direct Methylome Sequencing.Epigenomes · 2025Article
- Toward equitable biomarkers of aging: rethinking methylation clocks.Trends in genetics : TIG · 2025Article
- Association of Epigenetic Markers of Aging With Prevalent and Incident Type 2 Diabetes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
Abstract
Biological age (BA), a measure of functional capacity and prognostic of health outcomes that discriminates between individuals of the same chronological age (chronAge), has been estimated using a variety of biomarkers. Previous comparative studies have mainly used epigenetic models (clocks), we use ~1000 participants to compare fifteen omics ageing clocks, with correlations of 0.21-0.97 with chronAge, even with substantial sub-setting of biomarkers. These clocks track common aspects of ageing with 95% of the variance in chronAge being shared among clocks. The difference between BA and chronAge - omics clock age acceleration (OCAA) - often associates with health measures. One year's OCAA typically has the same effect on risk factors/10-year disease incidence as 0.09/0.25 years of chronAge. Epigenetic and IgG glycomics clocks appeared to track generalised ageing while others capture specific risks. We conclude BA is measurable and prognostic and that future work should prioritise health outcomes over chronAge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.