Evidence map›Paper›PMID 35073168›Full record

ReviewAnnual review of pathology2022

Precision Medicine in Low- and Middle-Income Countries.

Jerald P Radich, Edward Briercheck, Daniel T Chiu, Manoj P Menon, Olga Sala Torra, Cecilia C S Yeung, Edus H Warren

Abstract readReview
In one paragraph

Review in Annual review of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jerald P RadichGlobal Oncology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; email: jradich@fredhutch.org.
Edward BriercheckGlobal Oncology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; email: jradich@fredhutch.org.
Daniel T ChiuDepartments of Chemistry and Bioengineering, University of Washington, Seattle, WA 98195, USA.
Manoj P MenonGlobal Oncology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; email: jradich@fredhutch.org.
Olga Sala TorraClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Cecilia C S YeungClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Edus H WarrenGlobal Oncology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; email: jradich@fredhutch.org.

Funding

Project 3U54CA190146 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CASPER, COREY · 2014 to 2019
$4.1M
(PQ5) Effect of HIV infection on viral and host gene expression and antitumor immunity in Kaposi Sarcoma in AfricaR01CA217138 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PHIPPS, WARREN, WARREN, EDUS HOUSTON · 2017 to 2021
$2.8M
Digital PCR quantification of BCR-ABL for CML diagnosis and monitoring in a LMICs settingUH3CA211139 · NCI · UNIVERSITY OF WASHINGTON · PI CHIU, DANIEL T · 2019 to 2021
$2.3M
NCI NIH HHS R01 CA217138NCI NIH HHS U54 CA190146NCI NIH HHS UH3 CA211139
6 · The paper itself

Abstract

Most cancer cases occur in low- and middle-income countries (LMICs). The sophisticated technical and human infrastructure needed for optimal diagnosis, treatment, and monitoring of cancers is difficult enough in affluent countries; it is especially challenging in LMICs. In Western, educated, industrial, rich, democratic countries, there is a growing emphasis on and success with precision medicine, whereby targeted therapy is directed at cancers based on the specific genetic lesions in the cancer. Can such precision approaches be delivered in LMICs? We offer some examples of novel partnerships and creative solutions that suggest that precision medicine may be possible in LMICs given heavy doses of will, creativity, and persistence and a little luck.

Indexed as

Developing CountriesNeoplasmsHumansPovertyPrecision MedicinediagnosticsLMICsprecision medicine

Identifiers

PMID35073168
PMCPMC9275191

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.