SynthesisJournal of nephrology2022
How good is a living donor? Systematic review and meta-analysis of the effect of donor demographics on post kidney transplant outcomes.
Synthesis in Journal of nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Critical insights of ischemic time assessment in living-donor kidney transplantation.Journal of anesthesia · 2026Article
- Effects of ischemic time in living-donor kidney transplantation: a retrospective, propensity score-matched cohort study.Journal of anesthesia · 2026Article
- Exploring Perspectives on Kidney Donation: Medical and Non-Medical Students in Croatia.Journal of clinical medicine · 2026Article
- Long-Term Outcomes Across Age and Risk Profiles in a Caucasian Living Kidney Donor Cohort.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Transforming organ donation and transplantation: challenges, innovations, and future directions.Frontiers in transplantation · 2026Review
- Clinical outcomes of living kidney transplantation from donors aged 70 years and older: a Japanese multicenter study.Scientific reports · 2025Observational
- Outcomes of living donor kidney transplantation from extended criteria donors to extended criteria recipients: A retrospective cohort study.World journal of transplantation · 2025Article
- Expanding boundaries: The evolution and future of living donor kidney transplantation.World journal of transplantation · 2025Article
- Artificial intelligence assisted risk prediction in organ transplantation: a UK Live-Donor Kidney Transplant Outcome Prediction tool.Renal failure · 2025Article
- Comparison of outcomes after living and deceased donor kidney transplantation: UK national cohort study.The British journal of surgery · 2025Article
- Association between the Stanford Integrated Psychosocial Assessment for Transplant and 1-year medication nonadherence after living kidney transplantation.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Obesity-Related Kidney Disease in Bariatric Surgery Candidates.Obesity surgery · 2025Article
- Prediction of delayed graft function by early salivary microbiota following kidney transplantation.Applied microbiology and biotechnology · 2024Article
- Analyzing body composition in living kidney donors: impact on post-transplant kidney function.Frontiers in nephrology · 2024Article
- Diversity, Equity, and Inclusion in Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Outcomes of kidneys used for transplantation: an analysis of survival and function.Frontiers in transplantation · 2024Article
- Survival Advantage Comparing Older Living Donor Versus Standard Criteria Donor Kidney Transplants.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Living Donors' Age Modifies the Impact of Pre-Donation Estimated Glomerular Filtration Rate on Graft Survival.Journal of clinical medicine · 2023Article
- Body mass index affects kidney transplant outcomes: A cohort study over 5 years using a steroid sparing protocol.Frontiers in endocrinology · 2023Observational
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsLiving donor kidneys are considered the best quality organs. In the attempt to expand the donor pool, the donor's age, sex and body mass index (BMI) might be considered as potential determinants of the kidney transplant outcomes, and thus guide recipient selection. We aimed to investigate the effects of donor demographics on kidney function, graft and recipient survival, delayed graft function (DGF) and acute rejection (AR).
methodsSystematic review and meta-analysis. EMBASE, MEDLINE, Web of Science, BIOSIS, CABI, SciELO and Cochrane were searched using algorithms. NHBLI tools were used for risk of bias assessment. Mean difference (MD), standardized mean difference (SMD), and risk ratio (RR) were calculated in Revman 5.4
resultsAltogether, 5129 studies were identified by the search algorithm; 47 studies met the inclusion criteria and were analyzed. No significant difference in recipient 1-year survival was found between recipients of donors aged < 50 vs donors aged > 50 (RR = 0.65 95% CI: 0.1-4.1), and recipients of donors aged < 60 vs donors aged > 60 (RR = 0.81 95% CI: 0.3-2.3). Graft survival was significantly higher in recipients of grafts from donors aged < 60. Risk of AR (RR = 0.62 95% CI: 0.5-0.8) and DGF (RR = 0.28 95% CI: 0.1-0.9) were significantly lower in recipients of grafts from donors aged < 60. One-year serum creatinine was significantly lower in recipients from donors aged < 60 years compared to donors aged > 60 years (MD = 0.3 mg/dl 95% CI: 0.1-0.9), although there was high heterogeneity. Recipients of grafts from male donors had lower 1-year serum creatinine (MD = 0.12 mg/dl 95% CI: 0.2-0.1) and higher eGFR compared to recipients of female donors (p < 0.00001). Donor obesity increased the incidence of delayed graft function but not acute rejection (RR = 0.66 95% CI: 0.32-1.34).
conclusionsOlder donor age was associated with worse post-transplant outcomes and recipients of male donors had better 1-year eGFR. Donor obesity affects the incidence of delayed graft function, but not the incidence of acute rejection in recipients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.