ArticleeLife2022
Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
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Who cites it
46 citing papers in PubMed, 63 citations in OpenAlex.
- Gut microbial trimethylamine N-oxide generation promotes risk of atrial fibrillation via muscarinic receptor-mediated autonomic dysfunction.The Journal of clinical investigation · 2026Article
- Timekeepers of the gut: host circadian rhythms and microbial modulators.Life metabolism · 2026Review
- Signed, sealed, delivered: a generalizable model for living biotherapeutic dosing and metabolism.NPJ systems biology and applications · 2026Article
- Circadian rhythms and microbiota: molecular crosstalk and its implications for health and disease.Biology direct · 2026Review
- Gut microbe-derived trimethylamine shapes circadian rhythms through the host receptor TAAR5.eLife · 2026Article
- Gut Microbiota in the Hepato-Cardiorenal Axis: Microbial Metabolites, Inflammation, and Emerging Therapeutic Targets.Current pharmaceutical design · 2026Review
- Gut microbiota orchestrates bone homeostasis: a multi-pathway network from intestine to skeleton.Frontiers in endocrinology · 2026Review
- AI digital-twin ecosystem translating gut-microbiome-neuroimmune signals into precision sleep-mood interventions.Frontiers in psychiatry · 2026Review
- A comprehensive review of ischemic heart disease: pathophysiology, current treatments, natural products-based therapies, and nanotherapeutics.Frontiers in pharmacology · 2026Review
- Functional genetic signatures of the gut microbiome in cardiometabolic diseases: mechanisms and translational opportunities.Frontiers in microbiomes · 2026Review
- Article
- Circadian rhythms of gut microbiota and plaque vulnerability: mechanisms and chrono-microbiota modulation interventions.Gut microbes · 2025Review
- Gut microbiota, circadian rhythms and their interactions: implications for the pathogenesis and treatment of depression.Annals of medicine · 2025Review
- Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Health.Gastroenterology · 2025Review
- Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5.bioRxiv : the preprint server for biology · 2025Article
- All Roads Lead to Carbinolamine: QM/MM Study of Enzymatic C-N Bond Cleavage in Anaerobic Glycyl Radical Enzyme Choline Trimethylamine-Lyase (CutC).The journal of physical chemistry. B · 2025Article
- Dysregulation of the FGF21-Adiponectin Axis in a Large Cohort of Patients with Severe Obesity and Liver Disease.International journal of molecular sciences · 2025Article
- The gut-heart axis: a correlation between Paneth cells' dysfunction, microbiome dysbiosis, and cardiovascular diseases.Cell communication and signaling : CCS · 2025Review
- Severity of atopic dermatitis is associated with gut-derived metabolites and leaky gut-related biomarkers.Scientific reports · 2025Article
- Absolute Quantitative Lipidomics Reveals Differences in Lipid Compounds in the Blood of Trained and Untrained Yili Horses.Veterinary sciences · 2025Article
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Authors and funding
33 authors at 6 institutions in 2 countries.
Rebecca C Schugar *Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.ORCID 0000-0001-5908-2213
Christy M Gliniak *Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.ORCID 0000-0003-3806-6112
Lucas J Osborn *Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.ORCID 0000-0003-0077-9192
William MasseyDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.ORCID 0000-0002-2087-6048
Naseer SangwanDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Anthony HorakDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Rakhee BanerjeeDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Danny OrabiDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Robert N HelsleyDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.ORCID 0000-0001-5000-3187
Amanda L BrownDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Amy BurrowsDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Chelsea FinneyDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Kevin K FungDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Frederick M AllenDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Daniel FergusonDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Anthony D GromovskyDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Chase NeumannDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Kendall CookDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Amy McMillanDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Jennifer A BuffaDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
James T AndersonDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Margarete MehrabianDepartments of Medicine, Microbiology, and Human Genetics, University of California, Los Angeles, Los Angeles, United States.
Maryam GoudarziDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Belinda WillardDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Tytus D MakMass Spectrometry Data Center, National Institute of Standards and Technology (NIST), Gaithersburg, United States.
Andrew R ArmstrongDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, United States.
Garth SwansonDepartments of Medicine, Microbiology, and Human Genetics, University of California, Los Angeles, Los Angeles, United States.
Ali KeshavarzianDepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, United States.ORCID 0000-0002-7969-3369
Jose Carlos Garcia-GarciaLife Sciences Transformative Platform Technologies, Procter & Gamble, Cincinnati, United States.
Zeneng WangDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Aldons J LusisDepartments of Medicine, Microbiology, and Human Genetics, University of California, Los Angeles, Los Angeles, United States.
Stanley L HazenDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Jonathan Mark BrownDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.ORCID 0000-0003-2708-7487
Cleveland Clinic Lerner College of Medicine · USUniversity of California, Los Angeles · USRush University Medical Center · USCleveland Clinic · USNational Institute of Standards and Technology · USProcter & Gamble (Netherlands) · NL
Funding
TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Amar Desai · 1987 to 2026
$142.3MClinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MClinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5MTargeting 15-PGDH in Colon Cancer Prognosis, Prediction, Treatment and PreventionP50CA150964 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARKOWITZ, SANFORD D. · 2011 to 2022
$24.6MProject Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI LAURA E. NAGY · 2016 to 2026
$19.6MProject 3: Microbiota generated aryl sulfates and secondary bile acids in cardiometabolic diseaseP01HL147823 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MICHAEL ANDREW FISCHBACH · 2019 to 2026
$17.0MGut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8MENDOCRINE &METABOLISM TRAINING GRANTT32DK007307 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI PHILIPP E SCHERER · 1986 to 2026
$5.4MSystems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6MSystems genetics approach to inflammatory mechanisms in atherosclerosisR01HL147883 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2019 to 2022
$3.0MMetaorganismal Endocrinology in Cardiometabolic DiseaseR01DK130227 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Jonathan Mark Brown · 2021 to 2026
$2.8MGut microbiota and metabolite interactions in atherosclerosisR01HL144651 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, REY, FEDERICO E · 2019 to 2022
$2.6MNCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR002548NCI NIH HHS P30 CA043703NCI NIH HHS P50 CA150964NHLBI NIH HHS P01 HL146823NHLBI NIH HHS P01 HL147823NHLBI NIH HHS R01 HL103866NHLBI NIH HHS R01 HL130819NHLBI NIH HHS R01 HL144651NHLBI NIH HHS R01 HL147883NIAAA NIH HHS P50 AA024333NIAAA NIH HHS U01 AA026938NIDDK NIH HHS F32 DK122623NIDDK NIH HHS R01 DK117850NIDDK NIH HHS R01 DK120679NIDDK NIH HHS R01 DK130227NIDDK NIH HHS T32 DK007307
Abstract
Obesity has repeatedly been linked to reorganization of the gut microbiome, yet to this point obesity therapeutics have been targeted exclusively toward the human host. Here, we show that gut microbe-targeted inhibition of the trimethylamine N-oxide (TMAO) pathway protects mice against the metabolic disturbances associated with diet-induced obesity (DIO) or leptin deficiency (
Indexed as
AnimalsCholineCircadian RhythmDiet, High-FatEnzyme InhibitorsGastrointestinal MicrobiomeLeptinLyasesMaleMethylaminesMiceMice, Inbred C57BLObesityCholineEnzyme InhibitorsLeptinLyasesMethylaminesmethylcholinetrimethylaminetrimethyloxaminedrug deliverygenetic diseasesgut microbiomemedicinemousenutrition
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.