ArticleJournal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 532023
Subgenual Anterior Cingulate Cortex Reactivity to Rejection Vs. Acceptance Predicts Depressive Symptoms among Adolescents with an Anxiety History.
Article in Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- A Neurodevelopmental Model of Social Threat Sensitivity as a Mechanism Linking Fearful Temperament, Social Anxiety, and Depression in Youth.Journal of child and adolescent psychopharmacology · 2026Review
- Contextualizing the adolescent social brain: Links to social health using data from the Adolescent Brain Cognitive Development Study.Developmental cognitive neuroscience · 2026Article
- Gender-specific temporal dynamics of depressive symptoms and emotional resilience in adolescents: a cross-lagged network and simulation-based intervention study.Child and adolescent psychiatry and mental health · 2026Article
- Reduced amygdala habituation to anticipated social rejection in youth with major depressive disorder.Journal of affective disorders · 2026Article
- Momentary Peer Acceptance: An fMRI-EMA Integration Study of Peer Acceptance and Emotions.Child psychiatry and human development · 2026Article
- Adolescent empathy predicts reduced neural responses to social rejection in adulthood.Development and psychopathology · 2026Article
- Predictive value of subgenual cingulate normative connectivity to TMS treatment site for antidepressant response in routine clinical practice: a prospective, multisite cohort study.Molecular psychiatry · 2026Observational
- Article
- Emotional trade-offs of neural sensitivity to social threat and reward in adolescent girls.Social cognitive and affective neuroscience · 2025Article
- The Role of Neural Sensitivity to Social Evaluation in Understanding "for Whom" Social Media Use May Impact Emotional Health During Adolescence.Affective science · 2024Article
- Heightened neural activity and functional connectivity responses to social rejection in female adolescents at risk for depression: Testing the Social Signal Transduction Theory of Depression.Journal of affective disorders · 2024Article
- Script-driven imagery of socially salient autobiographical memories in major depressive disorder.Scientific reports · 2023Article
- Neural activation to peer acceptance and rejection in relation to concurrent and prospective depression risk in adolescent and pre-adolescent girls.Biological psychology · 2023Article
- Adolescents' neural reactivity to parental criticism is associated with diminished happiness during daily interpersonal situations.Social cognitive and affective neuroscience · 2023Article
- Neural sensitivity to peer feedback and depression symptoms in adolescents: a 2-year multiwave longitudinal study.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveThe goal of this study was to examine whether neural sensitivity to negative peer evaluation conveys risk for depression among youth with a history of anxiety. We hypothesized that brain activation in regions that process affective salience in response to rejection, relative to acceptance, from virtual peers would predict depressive symptoms 1 year later and would be associated with ecological momentary assessment (EMA) reports of peer connectedness.
methodParticipants were 38 adolescents ages 11-16 (50% female) with a history of anxiety, recruited from a previous clinical trial. The study was a prospective naturalistic follow-up of depressive symptoms assessed 2 years (Wave 2) and 3 years (Wave 3) following treatment. At Wave 2, participants completed the Chatroom Interact Task during neuroimaging and 16 days of EMA.
resultsControlling for depressive and anxiety symptoms at Wave 2, subgenual anterior cingulate (sgACC;
conclusionFindings suggest that elevated sgACC activation to negative, relative to positive, peer evaluation may serve as a risk factor for depressive symptoms among youth with a history of anxiety, perhaps by promoting vigilance or reactivity to social evaluative threats. SgACC activation to simulated peer evaluation appears to have implications for understanding how adolescents experience their daily social environments in ways that could contribute to depressive symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.