Evidence map›Paper›PMID 35072462›Full record

ArticleJournal of the American Chemical Society2022

Catalytic Activation of Bioorthogonal Chemistry with Light (CABL) Enables Rapid, Spatiotemporally Controlled Labeling and No-Wash, Subcellular 3D-Patterning in Live Cells Using Long Wavelength Light.

Andrew Jemas, Yixin Xie, Jessica E Pigga, Jeffrey L Caplan, Christopher W Am Ende, Joseph M Fox

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Control of Tetrazine Bioorthogonal Reactivity by Rotaxanation.Angewandte Chemie (International ed. in English) · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Low-energy photoredox catalysis.Nature reviews. Chemistry · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Andrew JemasDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Yixin XieDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Jessica E PiggaDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Jeffrey L CaplanDepartment of Plant and Soil Sciences and Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19716, United States.
Christopher W Am EndePfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.ORCID 0000-0001-8832-9641
Joseph M FoxDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0002-8258-1640
University of Delaware · USBiotechnology Institute · USPfizer (United States) · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
Toolkit for Fast, Multipurpose and Inducible Bioorthogonal ChemistryR01GM132460 · NIGMS · UNIVERSITY OF DELAWARE · PI JOSEPH M FOX · 2019 to 2026
$4.2M
High Sensitivity NMR Spectrometer with CryoprobeS10OD025185 · OD · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2019 to 2019
$930k
Multimodal PerkinElmer IVIS-SpectrumCT imaging system for a preclinical imaging core facilityS10OD026951 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YUAN, HONG · 2020 to 2020
$590k
Q-Exactive Orbitrap LC-MC/MS SystemS10OD016267 · OD · UNIVERSITY OF DELAWARE · PI JOHNSTON, MURRAY V · 2013 to 2013
$573k
Spinning Disk Confocal and Single Molecule Localization MicroscopeS10OD030321 · OD · UNIVERSITY OF DELAWARE · PI CAPLAN, JEFFREY L · 2021 to 2021
$562k
High Performance Digital NMR SpectrometerS10RR026962 · NCRR · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2010 to 2010
$500k
Zeiss LSM710 Inverted Confocal MicroscopeS10OD016361 · OD · UNIVERSITY OF DELAWARE · PI CAPLAN, JEFFREY L · 2015 to 2015
$444k
NCRR NIH HHS S10 RR026962NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM104316NIGMS NIH HHS R01 GM132460NIH HHS S10 OD016267NIH HHS S10 OD016361NIH HHS S10 OD025185NIH HHS S10 OD026951NIH HHS S10 OD030321
6 · The paper itself

Abstract

Described is the spatiotemporally controlled labeling and patterning of biomolecules in live cells through the catalytic activation of bioorthogonal chemistry with light, referred to as "CABL". Here, an unreactive dihydrotetrazine (DHTz) is photocatalytically oxidized in the intracellular environment by ambient O

Indexed as

LightCatalysisCycloaddition ReactionCyclooctanesEscherichia coliFluorescent DyesHeLa CellsHeterocyclic Compounds, 1-RingHumansKineticsLuminescent ProteinsMicroscopy, FluorescenceOxidation-ReductionCyclooctanesFluorescent DyesHeterocyclic Compounds, 1-RingLuminescent Proteins

Identifiers

PMID35072462
PMCPMC9364228
OpenAlexW4220816209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.