Evidence map›Paper›PMID 35072166›Full record

ArticleCommunications medicine2021

The antibody response to SARS-CoV-2 infection persists over at least 8 months in symptomatic patients.

Riccardo Levi, Leonardo Ubaldi, Chiara Pozzi, Giovanni Angelotti, Maria Teresa Sandri, Elena Azzolini, Michela Salvatici, Victor Savevski, Alberto Mantovani, Maria Rescigno

Open access · goldAbstract read
In one paragraph

Article in Communications medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Riccardo Levi *Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele Milano, Italy.
Leonardo Ubaldi *Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele Milano, Italy.
Chiara PozziIRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano Milano, Italy.ORCID 0000-0003-2153-6130
Giovanni AngelottiIRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano Milano, Italy.
Maria Teresa SandriDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele Milano, Italy.
Elena AzzoliniDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele Milano, Italy.ORCID 0000-0003-1257-8929
Michela SalvaticiIRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano Milano, Italy.
Victor SavevskiIRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano Milano, Italy.
Alberto MantovaniDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele Milano, Italy.ORCID 0000-0001-5578-236X
Maria RescignoDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele Milano, Italy.ORCID 0000-0002-6464-509X
Humanitas University · ITIRCCS Humanitas Research Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPersistence of antibodies to SARS-CoV-2 viral infection may depend on several factors and may be related to the severity of disease or to the different symptoms.

methodsWe evaluated the antibody response to SARS-CoV-2 in personnel from 9 healthcare facilities and an international medical school and its association with individuals' characteristics and COVID-19 symptoms in an observational cohort study. We enrolled 4735 subjects (corresponding to 80% of all personnel) for three time points over a period of 8-10 months. For each participant, we determined the rate of antibody increase or decrease over time in relation to 93 features analyzed in univariate and multivariate analyses through a machine learning approach.

resultsHere we show in individuals positive for IgG (≥12 AU/mL) at the beginning of the study an increase [

conclusionsSARS-CoV-2 infection induces a long lasting antibody response that increases in the first months, particularly in individuals with anosmia/dysgeusia. This may be linked to the lingering of SARS-CoV-2 in the olfactory bulb.

Indexed as

Computational biology and bioinformaticsEpidemiologyViral infection

Identifiers

PMID35072166
PMCPMC8767777
OpenAlexW3199602254

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.