Evidence map›Paper›PMID 35072136›Full record

ArticleCell genomics2021

GA4GH: International policies and standards for data sharing across genomic research and healthcare.

Heidi L Rehm, Angela J H Page, Lindsay Smith, Jeremy B Adams, Gil Alterovitz, Lawrence J Babb, Maxmillian P Barkley, Michael Baudis, Michael J S Beauvais, Tim Beck and 192 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 205 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

205 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Human cardiovascular organoids: Biomedical applications and ethical challenges.American heart journal plus : cardiology research and practice · 2026
    Review
  8. Genomic Data Governance Challenges Between Research and Clinical Care: A Scoping Review.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Participant Perspectives on Data Sharing in Clinical Craniofacial Research: Qualitative Interviews With Participants With Craniofacial Microsomia and Their Caregivers.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026
    Article
  20. Article

145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

202 authors.

Heidi L RehmBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Angela J H PageBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Lindsay SmithGlobal Alliance for Genomics and Health, Toronto, ON, Canada.
Jeremy B AdamsGlobal Alliance for Genomics and Health, Toronto, ON, Canada.
Gil AlterovitzBrigham and Women's Hospital, Boston, MA, USA.
Lawrence J BabbBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Maxmillian P BarkleyDNAstack, Toronto, ON, Canada.
Michael BaudisUniversity of Zurich, Zurich, Switzerland.
Michael J S BeauvaisGlobal Alliance for Genomics and Health, Toronto, ON, Canada.
Tim BeckUniversity of Leicester, Leicester, UK.
Jacques S BeckmannUniversity of Lausanne, Lausanne, Switzerland.
Sergi BeltranCNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
David BernickBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Alexander BernierMcGill University, Montreal, QC, Canada.
James K BonfieldWellcome Sanger Institute, Hinxton, UK.
Tiffany F BoughtwoodAustralian Genomics, Parkville, VIC, Australia.
Guillaume BourqueMcGill University, Montreal, QC, Canada.
Sarion R BowersWellcome Sanger Institute, Hinxton, UK.
Anthony J BrookesUniversity of Leicester, Leicester, UK.
Michael BrudnoCanadian Center for Computational Genomics, Montreal, QC, Canada.
Matthew H BrushOregon Health and Science University, Portland, OR, USA.
David BujoldMcGill University, Montreal, QC, Canada.
Tony BurdettEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Orion J BuskePhenoTips, Toronto, ON, Canada.
Moran N CabiliBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Daniel L CameronWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Robert J CarrollVanderbilt University Medical Center, Nashville, TN, USA.
Esmeralda Casas-SilvaKelly Government Solutions, Rockville, MD, USA.
Debyani ChakravartyMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Bimal P ChaudhariNationwide Children's Hospital, Columbus, OH, USA.
Shu Hui ChenNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
J Michael CherryStanford University, Stanford, CA, USA.
Justina ChungGlobal Alliance for Genomics and Health, Toronto, ON, Canada.
Melissa ClineUC Santa Cruz Genomics Institute, Santa Cruz, CA, USA.
Hayley L ClissoldWellcome Sanger Institute, Hinxton, UK.
Robert M Cook-DeeganArizona State University, Washington, DC, USA.
Mélanie CourtotEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Fiona CunninghamEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Miro CupakDNAstack, Toronto, ON, Canada.
Robert M DaviesWellcome Sanger Institute, Hinxton, UK.
Danielle DeniskoUniversity of Toronto, Toronto, ON, Canada.
Megan J DoerrSage Bionetworks, Seattle, WA, USA.
Lena I DolmanUniversity of Toronto, Toronto, ON, Canada.
Edward S DoveUniversity of Edinburgh, Edinburgh, UK.
L Jonathan DursiUniversity Health Network, Toronto, ON, Canada.
Stephanie O M DykeMcGill University, Montreal, QC, Canada.
James A EddySage Bionetworks, Seattle, WA, USA.
Karen EilbeckUniversity of Utah, Salt Lake City, UT, USA.
Kyle P EllrottOregon Health and Science University, Portland, OR, USA.
Susan FairleyGlobal Alliance for Genomics and Health, Toronto, ON, Canada.
Khalid A FakhroSidra Medicine, Doha, Qatar.
Helen V FirthWellcome Sanger Institute, Hinxton, UK.
Michael S FitzsimonsUniversity of Chicago, Chicago, IL, USA.
Marc FiumeDNAstack, Toronto, ON, Canada.
Paul FlicekEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Ian M ForeNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mallory A FreebergEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Robert R FreimuthMayo Clinic, Rochester, MN, USA.
Lauren A FromontCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Jonathan FuerthDNAstack, Toronto, ON, Canada.
Clara L GaffAustralian Genomics, Parkville, VIC, Australia.
Weiniu GanNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Elena M GhanaimNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
David GlazerVerily Life Sciences, South San Francisco, CA, USA.
Robert C GreenBrigham and Women's Hospital, Boston, MA, USA.
Malachi GriffithWashington University School of Medicine in St. Louis, St. Louis, MO, USA.
Obi L GriffithWashington University School of Medicine in St. Louis, St. Louis, MO, USA.
Robert L GrossmanUniversity of Chicago, Chicago, IL, USA.
Tudor GrozaPryzm Health, Sydney, QLD, Australia.
Jaime M Guidry AuvilNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Roderic GuigóUniversitat Pompeu Fabra (UPF), Barcelona, Spain.
Dipayan GuptaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Melissa A HaendelUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Ada HamoshJohns Hopkins University, Baltimore, MD, USA.
David P HansenAustralian Genomics, Parkville, VIC, Australia.
Reece K HartBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Dean Mitchell HartleyAutism Speaks, Princeton, NJ, USA.
David HausslerUC Santa Cruz Genomics Institute, Santa Cruz, CA, USA.
Rachele M Hendricks-SturrupDuke-Margolis Center for Health Policy, Washington, DC, USA.
Calvin W L HoThe University of Hong Kong, Hong Kong, Hong Kong.
Ashley E HobbDNAstack, Toronto, ON, Canada.
Michael M HoffmanUniversity of Toronto, Toronto, ON, Canada.
Oliver M HofmannUniversity of Toronto, Toronto, ON, Canada.
Petr HolubBBMRI-ERIC, Graz, Austria.
Jacob Shujui HsuNational Taiwan University, Taipei City, Taiwan.
Jean-Pierre HubauxÉcole polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Sarah E HuntEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Ammar HusamiCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Julius O JacobsenQueen Mary University of London, London, UK.
Saumya S JamuarSingHealth Duke-NUS Genomic Medicine Centre, Singapore, Republic of Singapore.
Elizabeth L JanesGlobal Alliance for Genomics and Health, Toronto, ON, Canada.
Francis JeansonDatadex Inc., Toronto, ON, Canada.
Aina JenéCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Amber L JohnsGarvan Institute of Medical Research, Darlinghurst, NSW, Australia.
Yann JolyMcGill University, Montreal, QC, Canada.
Steven J M JonesCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Alexander KanitzSIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Kazuto KatoOsaka University, Suita, Japan.
Thomas M KeaneEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Kristina Kekesi-LafranceGlobal Alliance for Genomics and Health, Toronto, ON, Canada.
Jerome KelleherUniversity of Oxford, Oxford, UK.
Giselle KerryEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Seik-Soon KhorNational Center for Global Health and Medicine Hospital, Tokyo, Japan.
Bartha M KnoppersMcGill University, Montreal, QC, Canada.
Melissa A KonopkoELIXIR Hub, Hinxton, UK.
Kenjiro KosakiKeio University School of Medicine, Tokyo, Japan.
Martin KubaMasaryk University, Brno, Czech Republic.
Jonathan LawsonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Rasko LeinonenEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Stephanie LiBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Michael F Linmlin.net LLC, San Jose, CA, USA.
Mikael LindenCSC-IT Center for Science, Espoo, Finland.
Xianglin LiuUniversity of Waterloo, Waterloo, ON, Canada.
Isuru Udara LiyanageEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Javier LopezGenomics England, London, UK.
Anneke M LucassenFaculty of Medicine, University Southampton, Southampton, UK.
Michael LukowskiUniversity of Chicago, Chicago, IL, USA.
Alice L MannGlobal Alliance for Genomics and Health, Toronto, ON, Canada.
John MarshallUniversity of Glasgow, Glasgow, UK.
Michele MattioniSeven Bridges, Boston, MA, USA.
Alejandro Metke-JimenezThe Australian e-Health Research Centre, CSIRO, Herston, QLD, Australia.
Anna MiddletonWellcome Connecting Science, Hinxton, UK.
Richard J MilneWellcome Connecting Science, Hinxton, UK.
Fruzsina Molnár-GáborHeidelberg Academy of Sciences and Humanities, Heidelberg, Germany.
Nicola MulderH3ABioNet, Computational Biology Division, IDM, Faculty of Health Sciences, Cape Town, South Africa.
Monica C Munoz-TorresUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Rishi NagEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Hidewaki NakagawaJapan Agency for Medical Research & Development (AMED), Tokyo, Japan.
Jamal NasirUniversity of Northampton, Northampton, UK.
Arcadi NavarroCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Tristan H NelsonGenomic Medicine Institute, Geisinger, Danville, PA, USA.
Ania NiewielskaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Amy NisselleMurdoch Children's Research Institute, Parkville, VIC, Australia.
Jeffrey NiuUniversity Health Network, Toronto, ON, Canada.
Tommi H NyrönenCSC-IT Center for Science, Espoo, Finland.
Brian D O'ConnorBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sabine OesterleSIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Soichi OgishimaTohoku University, Sendai, Japan.
Vivian Ota WangNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Laura A D PaglioneSpherical Cow Group, New York, NY, USA.
Emilio PalumboUniversitat Pompeu Fabra (UPF), Barcelona, Spain.
Helen E ParkinsonEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Anthony A PhilippakisBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Angel D PizarroAmazon Web Services, Inc., Seattle, WA, USA.
Andreas PrlicInvitae, San Francisco, CA, USA.
Jordi RamblaUniversitat Pompeu Fabra (UPF), Barcelona, Spain.
Augusto RendonGenomics England, London, UK.
Renee A RiderNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Peter N RobinsonThe Jackson Laboratory, Farmington, CT, USA.
Kurt W RodarmerNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Laura Lyman RodriguezPatient-Centered Outcomes Research Institute (PCORI), Washington, DC, USA.
Alan F RubinWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Manuel RuedaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Gregory A RushtonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Rosalyn S RyanBicgen Foundation Inc, Arlington Heights, IL, USA.
Gary I SaundersELIXIR Hub, Hinxton, UK.
Helen SchuilenburgEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Torsten SchwedeSIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Serena ScollenELIXIR Hub, Hinxton, UK.
Alexander SenfCongenica Ltd., Cambridge, UK.
Nathan C SheffieldUniversity of Virginia, Charlottesville, VA, USA.
Neerjah SkantharajahGlobal Alliance for Genomics and Health, Toronto, ON, Canada.
Albert V SmithUniversity of Michigan, Ann Arbor, MI, USA.
Heidi J SofiaNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Dylan SpaldingCSC-IT Center for Science, Espoo, Finland.
Amanda B SpurdleQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Zornitza StarkAustralian Genomics, Parkville, VIC, Australia.
Lincoln D SteinOntario Institute for Cancer Research, Toronto, ON, Canada.
Makoto SuematsuKeio University School of Medicine, Tokyo, Japan.
Patrick TanSingHealth Duke-NUS Genomic Medicine Centre, Singapore, Republic of Singapore.
Jonathan A TeddsELIXIR Hub, Hinxton, UK.
Alastair A ThomsonNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Adrian ThorogoodMcGill University, Montreal, QC, Canada.
Timothy L TickleBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Katsushi TokunagaUniversity of Tokyo, Tokyo, Japan.
Juha TörnroosCSC-IT Center for Science, Espoo, Finland.
David TorrentsInstitució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.
Sean UpchurchCalifornia Institute of Technology, Pasadena, CA, USA.
Alfonso ValenciaInstitució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.
Roman Valls GuimeraUniversity of Melbourne, Melbourne, VIC, Australia.
Jessica VamathevanEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Susheel VarmaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Danya F VearsMurdoch Children's Research Institute, Parkville, VIC, Australia.
Coby VinerUniversity of Toronto, Toronto, ON, Canada.
Craig VoisinGoogle LLC, Kitchener, ON, Canada.
Alex H WagnerNationwide Children's Hospital, Columbus, OH, USA.
Susan E WallaceUniversity of Leicester, Leicester, UK.
Brian P WalshOregon Health and Science University, Portland, OR, USA.
Marc S WilliamsGenomic Medicine Institute, Geisinger, Danville, PA, USA.
Eva C WinklerSection of Translational Medical Ethics, University Hospital Heidelberg, Heidelberg, Germany.
Barbara J WoldCalifornia Institute of Technology, Pasadena, CA, USA.
Grant M WoodSalt Lake City, UT, USA.
J Patrick WoolleyUniversity of Oxford, Oxford, UK.
Chisato YamasakiOsaka University, Suita, Japan.
Andrew D YatesEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
Christina K YungOntario Institute for Cancer Research, Toronto, ON, Canada.
Lyndon J ZassH3ABioNet, Computational Biology Division, IDM, Faculty of Health Sciences, Cape Town, South Africa.
Ksenia ZaytsevaMcGill University, Montreal, QC, Canada.
Junjun ZhangOntario Institute for Cancer Research, Toronto, ON, Canada.
Peter GoodhandGlobal Alliance for Genomics and Health, Toronto, ON, Canada.
Kathryn NorthMurdoch Children's Research Institute, Parkville, VIC, Australia.
Ewan BirneyEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Enhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7M
The AnVIL Data Ecosystem DACReS SupplementU24HG010262 · NHGRI · BROAD INSTITUTE, INC. · PI Robert J Carroll, Jonathan Lawson · 2018 to 2026
$40.5M
CD2H - The National COVID Cohort Collaborative (N3C) IDeA CTR CollaborationU24TR002306 · NCATS · UNIVERSITY OF COLORADO DENVER · PI CHUTE, CHRISTOPHER G, EDDY, JAMES A · 2017 to 2021
$28.9M
Resource ProjectU41HG006834 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARTIN, CHRISTA LESE, REHM, HEIDI L · 2013 to 2020
$26.9M
Technology to understand genetic variant effects in contextRM1HG010461 · NHGRI · UNIVERSITY OF WASHINGTON · PI Douglas M Fowler, Bruce Colston Trapnell · 2019 to 2026
$18.9M
Resource ProjectU41HG006627 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI HAMOSH, ADA · 2012 to 2021
$18.0M
The Monarch Initiative: Linking Diseases to Model Organism ResourcesR24OD011883 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2012 to 2024
$16.0M
Baylor-Johns Hopkins Center for Mendelian GeneticsU54HG006542 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2012 to 2015
$15.6M
Higher Precision Human and Mouse TranscriptomesUM1HG009443 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MORTAZAVI, SEYED ALI, WOLD, BARBARA J · 2017 to 2021
$15.5M
Training SubprojectU54HG007990 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H, PATTERSON, DAVID · 2014 to 2018
$14.8M
H3ABioNet: informatics solutions for H3AfricaU24HG006941 · NHGRI · UNIVERSITY OF CAPE TOWN · PI MULDER, NICOLA · 2017 to 2021
$12.9M
CCR NIH HHS HHSN261200800001CMedical Research Council MC_PC_19024Medical Research Council MR/S003703/1NCATS NIH HHS U24 TR002306NCI NIH HHS 75N91019D00024NCI NIH HHS HHSN261200800001ENCI NIH HHS HHSN261201000031CNCI NIH HHS HHSN261201400008CNCI NIH HHS HHSN261201500001CNCI NIH HHS HHSN261201500001GNCI NIH HHS HHSN261201500001WNCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003INCI NIH HHS R01 CA237118NCI NIH HHS U01 CA242954NCI NIH HHS U13 CA221044NCI NIH HHS U24 CA231877NCI NIH HHS U24 CA237719NHGRI NIH HHS K99 HG010157NHGRI NIH HHS R00 HG007940NHGRI NIH HHS R00 HG010157NHGRI NIH HHS R35 HG011899NHGRI NIH HHS R35 HG011949NHGRI NIH HHS RM1 HG010461NHGRI NIH HHS RM1 HG010860NHGRI NIH HHS U24 HG006941NHGRI NIH HHS U24 HG010262NHGRI NIH HHS U24 HG011025NHGRI NIH HHS U41 HG006627NHGRI NIH HHS U41 HG006834NHGRI NIH HHS U54 HG006542NHGRI NIH HHS U54 HG007990NHGRI NIH HHS UM1 HG009443NHLBI NIH HHS OT3 HL142478NIGMS NIH HHS R35 GM128636NIH HHS R24 OD011883NIH HHS U2C OD023196Wellcome Trust 108749Wellcome Trust 201535Wellcome Trust 206194Wellcome Trust 220544
6 · The paper itself

Abstract

The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits.

Identifiers

PMID35072136
PMCPMC8774288

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.