Evidence map›Paper›PMID 35072126›Full record

ArticleResuscitation plus2022

Peri-arrest bolus epinephrine practices amongst pediatric resuscitation experts.

Catherine E Ross, Margaret M Hayes, Monica E Kleinman, Michael W Donnino, Amy M Sullivan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Current use of push-dose epinephrine: Survey and interview results from academic clinicians in emergency medicine.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Catherine E RossDivision of Medicine Critical Care, Department of Pediatrics Boston Children's Hospital and Harvard Medical School, 333 Longwood Avenue, Boston, MA 02115, USA.
Margaret M HayesDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, USA.
Monica E KleinmanDivision of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Michael W DonninoCenter for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 359 Brookline Avenue, Boston, MA 02115, USA.
Amy M SullivanDepartment of Medicine and Carl J. Shapiro Institute for Research and Education, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, USA.
Boston Children's Hospital · USHarvard University · USBeth Israel Deaconess Medical Center · US

Funding

Thaimine as an adjunct metabolic resuscitator in cardiac arrestK24HL127101 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DONNINO, MICHAEL WILLIAM · 2015 to 2024
$1.2M
Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect TrialK23HL148312 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI ROSS, CATHERINE · 2020 to 2024
$1.0M
NHLBI NIH HHS K23 HL148312NHLBI NIH HHS K24 HL127101
6 · The paper itself

Abstract

aimTo describe current practices of peri-arrest bolus epinephrine use amongst pediatric resuscitation experts in a multinational survey.

methodsA 9-question survey was developed and electronically distributed to pediatric critical care physicians who are site investigators for the Pediatric Resuscitation Quality Collaborative (pediRES-Q) network. Institutional demographics were collected through the American Hospital Association 2018 Annual Survey and linked to responses. Descriptive statistics were used to characterize closed-ended responses, and qualitative content analysis to analyze open-ended responses.

resultsOf the 63 collaborative members invited to participate, 49 (78%) responded, representing 35 institutions in 9 countries. Forty-six of the 49 respondents (94%) reported that they would consider using peri-arrest bolus epinephrine during critical situations in patients

conclusionsIn this multinational survey of pediatric resuscitation experts, endorsement of peri-arrest bolus epinephrine use was nearly universal, though a few clinicians cited lack of evidence to support this practice. There was a 100-fold difference in the range of initial weight-based doses reported, as well as a minority of clinicians who reported using non-weight-based dosing. Further research is needed to determine best practices, standardization of initial dosing, clinical factors that may warrant dosing modifications and associations with clinically important outcomes.

Indexed as

Critical CareHypotensionPediatricPeri-arrest bolus epinephrine

Identifiers

PMID35072126
PMCPMC8763627
OpenAlexW4205741145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.