Evidence map›Paper›PMID 35072121›Full record

ArticleForces in mechanics2021

A three-dimensional finite element model of cAMP signals.

R Warren, T C Rich, S J Leavesley, A-V Phan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Forces in mechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

R WarrenDepartment of Mechanical, Aerospace and Biomedical Engineering, University of South Alabama, Mobile, AL 36688, USA.
T C RichCenter for Lung Biology & Department of Pharmacology, University of South Alabama, Mobile, AL 36688, USA.
S J LeavesleyCenter for Lung Biology & Department of Pharmacology, University of South Alabama, Mobile, AL 36688, USA.
A-V PhanDepartment of Mechanical, Aerospace and Biomedical Engineering, University of South Alabama, Mobile, AL 36688, USA.
University of South Alabama · US

Funding

T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F. · 2001 to 2022
$34.6M
G Protein-Coupled Receptor Signaling in Airway Smooth MuR01HL058506 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAYMOND B. PENN · 2001 to 2026
$9.3M
Request for a Spectral Confocal MicroscopeS10RR027535 · NCRR · UNIVERSITY OF SOUTH ALABAMA · PI RICH, THOMAS C · 2010 to 2010
$397k
Andor Revolution WD Confocal Imaging SystemS10OD020149 · OD · UNIVERSITY OF SOUTH ALABAMA · PI TAYLOR, MARK STEPHEN · 2015 to 2015
$395k
NCRR NIH HHS S10 RR027535NHLBI NIH HHS P01 HL066299NHLBI NIH HHS R01 HL058506NIH HHS S10 OD020149
6 · The paper itself

Abstract

This paper presents a three-dimensional finite element model for cyclic adenosine monophosphate (cAMP) signaling. Governing equations for the synthesis, diffusion, and degradation of cAMP were numerically implemented using the finite element method. Simulated results were displayed as time course plots of cAMP concentrations at selected nodes within the discretized geometry. The validity of the finite element model was assessed by comparing simulated results against analytical or other numerical solutions of cAMP concentration distribution for a spherical cellular volume. An endothelial cell was also simulated using its discretized geometry obtained from microscopic cellular cross-sectional images. Simulated solutions using the spherical cellular volume produced near identical cAMP concentration plots to the analytical solutions and were in good agreements with numerical results obtained from VCell, an existing software package for modeling cell biological systems. The validated 3-D finite element model was then employed to simulate the cAMP signaling pathway within a pulmonary microvascular endothelial cell geometry.

Indexed as

cAMP intracellular signalingEndothelial cellsFinite element analysisPulmonary vasculatureSecond messenger signals

Identifiers

PMID35072121
PMCPMC8773462
OpenAlexW3196799229

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.