Evidence map›Paper›PMID 35072112›Full record

ArticleSTAR protocols2022

A simplified protocol for performing MAGMA/H-MAGMA gene set analysis utilizing high-performance computing environments.

Siwei Zhang

Abstract read
In one paragraph

Article in STAR protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Siwei ZhangCenter for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA.

Funding

Systematic Functional Interpretation of Regulatory Variants in SchizophreniaR01MH106575 · NIMH · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DUAN, JUBAO · 2016 to 2025
$6.1M
Modeling Alzheimer's disease genetic variants in hiPSCR01AG063175 · NIA · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DUAN, JUBAO, THINAKARAN, GOPAL · 2019 to 2023
$3.7M
Integrating epigenomics with DNA breathing dynamics for human non-coding disease variantsR01MH116281 · NIMH · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI ALEXANDROV, BOIAN STOIANOV, DUAN, JUBAO · 2019 to 2023
$3.0M
Genetic Perturbation of a Schizophrenia Susceptibility Locus in Isogenic Human NeR21MH102685 · NIMH · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DUAN, JUBAO · 2014 to 2015
$429k
NIA NIH HHS R01 AG063175NIMH NIH HHS R01 MH106575NIMH NIH HHS R01 MH116281NIMH NIH HHS R21 MH102685
6 · The paper itself

Abstract

Here, we present a quick-start protocol to perform generalized gene-set analysis of GWAS data on a metaset of gene lists generated by upstream pipelines, such as differential expression analysis, using the Multi-marker Analysis of GenoMic Annotation (MAGMA) software package and Hi-C coupled H-MAGMA annotation data (de Leeuw et al., 2015; Sey et al., 2020). We specifically tailor the steps and operations to meet the multithreading capability in modern computers, a feature nowadays shared by personal computers and high-performance clusters alike. For complete details on the use and execution of this profile, please refer to Yao et al. (2021).

Indexed as

GenomicsSoftwareComputersBioinformaticsGeneticsGenomicsNeuroscience

Identifiers

PMID35072112
PMCPMC8761752

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.