ReviewArchives of academic emergency medicine2022
Incidence of Pediatric Perforated Appendicitis during the COVID-19 Pandemic; a Systematic Review and Meta-Analysis.
Review in Archives of academic emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Spontaneous Resolution of Uncomplicated Appendicitis may Explain Increase in Proportion of Complicated Appendicitis During Covid-19 Pandemic: a Systematic Review and Meta-analysis.World journal of surgery · 2023Pooled it
- Neutrophil-to-lymphocyte ratio as an adjunct to clinical scoring systems for diagnosing perforated appendicitis in children: prospective cohort study.Annals of medicine and surgery (2012) · 2025Article
- Acute Appendicitis in Children During War Conflict: Results from a Multicenter Study.Journal of clinical medicine · 2025Article
- Impact of the novel coronavirus infection on pediatric surgery: an analysis of data from the National Clinical Database.Surgery today · 2024Article
- The impact of COVID-19 on racial and ethnic disparities in presentation with perforated appendicitis in children: A retrospective cohort study.Surgery open science · 2024Article
- Impact of COVID-19 on acute appendicitis presentation, management and pathology findings in adult and paediatric populations.PloS one · 2024Article
- Reasons for Delayed Diagnosis of Pediatric Acute Appendicitis during the COVID-19 Era: A Narrative Review.Diagnostics (Basel, Switzerland) · 2023Review
- Management of pediatric appendicitis during the COVID-19 pandemic: A nationwide multicenter cohort study.Journal of pediatric surgery · 2023Article
- Acute Appendicitis Following COVID-19 Infection in Pediatric Patients: A Single Center's Study in Greece.Diagnostics (Basel, Switzerland) · 2023Article
- A critical appraisal on the treatment of acute appendicitis in pediatric population during the COVID-19 pandemic.Annals of medicine and surgery (2012) · 2023Article
- Incidence of rheumatic diseases during the COVID-19 pandemic in South Korea.The Korean journal of internal medicine · 2023Article
- Analysis of articles in the Journal of Archives of Academic Emergency Medicine in 2022.Archives of academic emergency medicine · 2023Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCOVID-19 has affected the pattern of referral to medical centers and quarantine against COVID-19 might delay referral and management of surgical emergencies. This study aimed to compare the pooled event rate of pediatric perforated appendicitis before and during the COVID-19 pandemic.
methodsThis was a systematic review and meta-analysis study based on the PRISMA guidelines. Scopus, Web of Sciences, and PubMed databases were searched for studies reporting the rate of perforated appendicitis based on the post-appendectomy observations or imaging methods. The Egger bias test and funnel plot were used to detect and depict publication bias. Statistical analysis was performed in Comprehensive Meta-analysis package version 3.
resultsTwelve studies were eligible for inclusion in our study. The pooled prevalence of pediatric perforated appendicitis in the pre-COVID era was 28.5% (CI95%: 28.3 to 28.7%) with a heterogeneity of 99%. In the COVID era, the event rate proportion was 39.4% (CI95%: 36.6 to 42.3%) with a heterogeneity of 99%. There was a significant difference in the subgroup analysis within the pre-COVID and COVID era (P<0.001), showing a higher perforation rate in the COVID era.
conclusionOur study showed that during the COVID-19 pandemic, the rate of perforated appendicitis has significantly increased in comparison to before the COVID-19 pandemic.
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Registered trials
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