Evidence map›Paper›PMID 35072030›Full record

ReviewCJC open2022

Sex Differences in Implantation and Outcomes of Cardiac Resynchronization Therapy in Real-World Settings: A Systematic Review of Cohort Studies.

Omar Dewidar, Haben Dawit, Victoria Barbeau, David Birnie, Vivian Welch, George A Wells

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CJC open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Pacemaker Status and 5-Year Mortality After TAVI: A Sex-Specific Analysis.European journal of clinical investigation · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Saving women's hearts: Improving outcomes with prevention & policy.American journal of preventive cardiology · 2023
    Article
  10. Mitral Regurgitation in Female Patients: Sex Differences and Disparities.Journal of the Society for Cardiovascular Angiography & Interventions
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Omar DewidarSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Haben DawitSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Victoria BarbeauBruyère Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
David BirnieDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Vivian WelchSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
George A WellsSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
University of Ottawa · CABruyère · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence from randomized trials is conflicting on the effects of cardiac resynchronization therapy (CRT) by sex, and differences in access are unknown. We examined sex differences in the implantation rates and outcomes in patients treated with CRT using cohort studies.

methodsWe followed a pre-specified protocol (International Prospective Register of Systematic Reviews [PROSPERO]: CRD42020204804). MEDLINE, Embase, and Web of Science were searched for cohort studies from January 2000 to June 2020 that evaluated the response to CRT in patients ≥ 18 years old and reported sex-specific information in any language.

resultsWe included 97 studies (1,172,654 men and 486,553 women). Men received CRT more frequently than women (median ratio, 3.16; 25th to 75th interquartile range, 2.48-3.62). In the unadjusted analysis, men had a greater long-term all-cause mortality rate after CRT, compared with women (hazard ratio [HR], 1.50; 95% confidence interval [CI], 1.38-1.63;

conclusionsWe found in this large meta-analysis that men were more often implanted with CRT than women, yet men had a higher long-term all-cause mortality following CRT, compared with women, and smaller improvement in left ventricular ejection fraction. Reasons for this difference in implantation rates of CRT in real-world practice need to be investigated.

Identifiers

PMID35072030
PMCPMC8767135
OpenAlexW3200790587

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.