Evidence map›Paper›PMID 35072016›Full record

ArticleiScience2022

Metabolic signatures of regulation by phosphorylation and acetylation.

Kirk Smith, Fangzhou Shen, Ho Joon Lee, Sriram Chandrasekaran

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  9. Research square · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kirk SmithDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Fangzhou ShenDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Ho Joon LeeDepartment of Genetics, Yale University, New Haven, CT 06510, USA.
Sriram ChandrasekaranDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan · USYale University · US

Funding

Linking metabolic activity with drug sensitivity using metabolic influence networksR35GM137795 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sriram Chandrasekaran · 2020 to 2026
$2.6M
6 · The paper itself

Abstract

Acetylation and phosphorylation are highly conserved posttranslational modifications (PTMs) that regulate cellular metabolism, yet how metabolic control is shared between these PTMs is unknown. Here we analyze transcriptome, proteome, acetylome, and phosphoproteome datasets in

Indexed as

Metabolic flux analysisOmicsSystems biology

Identifiers

PMID35072016
PMCPMC8762462
OpenAlexW4226038902

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.