Evidence map›Paper›PMID 35071850›Full record

ArticleCurrent opinion in biomedical engineering2021

Mathematical and Computational Modeling of Device-Induced Thrombosis.

Keefe B Manning, Franck Nicoud, Susan M Shea

Open access · greenAbstract read
In one paragraph

Article in Current opinion in biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Protruding Objects in the Membrane Lung Outlet May Increase Thrombogenicity: Fluid Dynamical Insights.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. [Progress in the analysis of hemolysis and coagulation models for interventional micro-axial flow blood pumps].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024
    Review
  7. Article
  8. Influence of Hematocrit Level and Integrin αCellular and molecular bioengineering · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes.International journal for numerical methods in biomedical engineering · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Keefe B ManningDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Franck NicoudCNRS, IMAG, Université de Montpellier, Montpellier, France.
Susan M SheaDivision of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Centre National de la Recherche Scientifique · FRPennsylvania State University · USWashington University in St. Louis · US

Funding

A Structured Approach to the Design of Minimally Traumatic Blood PumpsR01HL136369 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CYSYK, JOSHUA P, MANNING, KEEFE B · 2018 to 2021
$2.6M
NHLBI NIH HHS R01 HL136369
6 · The paper itself

Abstract

Given the extensive and routine use of cardiovascular devices, a major limiting factor to their success is the thrombotic rate that occurs. This both poses direct risk to the patient and requires counterbalancing with anticoagulation and other treatment strategies, contributing additional risks. Developing a better understanding of the mechanisms of device-induced thrombosis to aid in device design and medical management of patients is critical to advance the ubiquitous use and durability. Thus, mathematical and computational modelling of device-induced thrombosis has received significant attention recently, but challenges remain. Additional areas that need to be explored include microscopic/macroscopic approaches, reconciling physical and numerical timescales, immune/inflammatory responses, experimental validation, and incorporating pathologies and blood conditions. Addressing these areas will provide engineers and clinicians the tools to provide safe and effective cardiovascular devices.

Indexed as

Cardiovasculardevicesmodellingthrombosis

Identifiers

PMID35071850
PMCPMC8769491
OpenAlexW3203062732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.