Evidence map›Paper›PMID 35071699›Full record

ArticleData in brief2022

Gene expression data of inflammatory mediators in apical periodontitis in 129 (wild type) and 5-lipoxygenase knockout mice.

Thaise Mayumi Taira, Vítor Luís Ribeiro, Yuri Jivago Silva Ribeiro, Raquel Assed Bezerra da Silva, Léa Assed Bezerra da Silva, Marília Pacífico Lucisano Politi, Lúcia Helena Faccioli, Francisco Wanderley Garcia Paula-Silva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Thaise Mayumi TairaDepartment of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil.
Vítor Luís RibeiroDepartment of Restorative Dentistry, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Yuri Jivago Silva RibeiroDepartment of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil.
Raquel Assed Bezerra da SilvaDepartment of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil.
Léa Assed Bezerra da SilvaDepartment of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil.
Marília Pacífico Lucisano PolitiDepartment of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil.
Lúcia Helena FaccioliDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas da Faculdade de Ciências Farmacêuticas de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Francisco Wanderley Garcia Paula-SilvaDepartment of Pediatric Clinics, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Café s/n, 1° andar, sala M-28, CEP, São Paulo 14040-904, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apical periodontitis is an immune inflammatory response around periapical tissues as a result of pathogens invasion into the root canal. The host immunoinflammatory response could determine the progression of this disease, which involves the recruitment of immune cells, and the release of several cytokines in the lesion site. The 5-lipoxygenase pathway has been activated in some osteolytic diseases due to its capacity to interfere in the proliferation and differentiation of bone cells, including the osteoclasts. As mean to understand the inflammatory genes regulation in the apical periodontitis progression, we evaluated the network of 66 genes related to cytokines, chemokines and other inflammatory mediators and receptors in the wild-type (WT) and 5-lipoxygenase enzyme genetically deficient mice (KO). This article presents data not published but related to the research article "Effects of 5-lipoxygenase gene disruption on inflammation, osteoclastogenesis and bone resorption in polymicrobial apical periodontitis" .

Indexed as

Arachidonic acidBone resorptionInflammationLeukotrienes

Identifiers

PMID35071699
PMCPMC8762048
OpenAlexW4206500546

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.