Evidence map›Paper›PMID 35071680›Full record

ArticleOpen forum infectious diseases2022

Clinical and Pregnancy Outcomes of Coronavirus Disease 2019 Among Hospitalized Pregnant Women in the United States.

Christina M Ackerman, Jennifer L Nguyen, Swapna Ambati, Maya Reimbaeva, Birol Emir, Javier Cabrera, Michael Benigno, Deepa Malhotra, Jennifer Hammond, Mert Ozan Bahtiyar

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. COVID-19 disease and vaccination in pregnant and lactating women.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Christina M AckermanDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA.
Jennifer L NguyenPfizer Inc, New York, New York, USA.ORCID https://orcid.org/0000-0002-4064-0227
Swapna AmbatiEliassen Group, Somerset, New Jersey, USA.
Maya ReimbaevaPfizer Inc, New York, New York, USA.
Birol EmirPfizer Inc, New York, New York, USA.
Javier CabreraDepartment of Statistics Rutgers University, New Brunswick, New Jersey, USA.
Michael BenignoPfizer Inc, New York, New York, USA.
Deepa MalhotraPfizer Inc, New York, New York, USA.
Jennifer HammondPfizer Inc, Collegeville, Pennsylvania, USA.
Mert Ozan BahtiyarDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA.
Pfizer (United States) · USYale University · USRutgers, The State University of New Jersey · US

Funding

Cardiovascular Health After Placental Abruption (CHAP)R01HL150065 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ANANTH, CANDE V., KOSTIS, WILLIAM J · 2020 to 2023
$2.8M
NHLBI NIH HHS R01 HL150065
6 · The paper itself

Abstract

backgroundPregnant women with coronavirus disease 2019 (COVID-19) may be at greater risk of poor maternal and pregnancy outcomes. This retrospective analysis reports clinical and pregnancy outcomes among hospitalized pregnant women with COVID-19 in the United States.

methodsThe Premier Healthcare Database-Special Release was used to examine the impact of COVID-19 among pregnant women aged 15-44 years who were hospitalized and who delivered compared with pregnant women without COVID-19. Outcomes evaluated were COVID-19 clinical progression, including the use of supplemental oxygen therapy, intensive care unit admission, critical illness, receipt of invasive mechanical ventilation/extracorporeal membrane oxygenation, maternal death, and pregnancy outcomes, including preterm delivery and stillbirth.

resultsOverall, 473 902 hospitalized pregnant women were included, 8584 (1.8%) of whom had a COVID-19 diagnosis (mean age = 28.4 [standard deviation = 6.1] years; 40% Hispanic). The risk of poor clinical and pregnancy outcomes was greater among pregnant women with COVID-19 compared with pregnant women without a COVID-19 diagnosis in 2020; the risk of poor clinical and pregnancy outcomes increased with increasing age. Hispanic and Black non-Hispanic women were consistently observed to have the highest relative risk of experiencing poor clinical or pregnancy outcomes across all age groups.

conclusionsOverall, COVID-19 had a significant negative impact on maternal health and pregnancy outcomes. These data help inform clinical practice and counseling to pregnant women regarding the risks of COVID-19. Clinical studies evaluating the safety and efficacy of vaccines against severe acute respiratory syndrome coronavirus 2 in pregnant women are urgently needed.

Indexed as

clinical outcomesCOVID-19hospitalizationpregnancy outcomes

Identifiers

PMID35071680
PMCPMC8522379
OpenAlexW3198708762

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.