ReviewFrontiers in medicine2021
Low Birthweight as a Risk Factor for Non-communicable Diseases in Adults.
Review in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- Joint Associations of Maternal Smoking and Pre-Pregnancy BMI with Term Low Birthweight and Small-for-Gestational-Age Births: A Cross-Sectional Analysis of 2024 United States Birth Data.International journal of environmental research and public health · 2026Article
- Low birth weight, DNA methylation patterns in cord blood, and inflammation at birth.Translational pediatrics · 2026Article
- Gestational Hypertension as a Mediator of Prenatal Ozone Exposure and Term Low Birth Weight: Birth Cohort Study.JMIR public health and surveillance · 2026Article
- Article
- Gestational fine particulate matter exposure and perinatal outcomes in the ECHO cohort: Associations across pregnancy windows.Environmental research · 2026Article
- Impact of Wildland Fire Smoke PMEnvironmental science & technology · 2026Article
- Dental caries incidence in infants with abnormal birth weight for gestational age: a longitudinal study in the Japan Environment and Children's Study.Environmental health and preventive medicine · 2026Article
- Perinatal vulnerability: its impact on oral and craniofacial hard tissue development.Frontiers in physiology · 2026Review
- Factors Associated With Low Birth Weight in Cambodia: A Secondary Analysis of the Cambodia Demographic and Health Survey, 2021-2022.Journal of pregnancy · 2026Article
- Article
- Nutrient Intake Evidence in the Pacific: A Scoping Review of Research Coverage, Challenges, and Opportunities.Food science & nutrition · 2026Article
- Taxing for healthier beginnings: The impact of a major tobacco tax hike on birth weight in Mexico.SSM - population health · 2025Article
- Prenatal exposure to metals and metal mixtures influences birth weight in affected populations in the Republic of Suriname, South America.Environmental research · 2025Article
- Differential Effects of Gynecological and Chronological Age on Low Birth Weight and Small for Gestational Age.Biomedicines · 2025Article
- Breastfeeding experience, barriers, and facilitators among mothers of vulnerable low birth weight infants in Amhara region, Ethiopia: a qualitative exploratory study.International breastfeeding journal · 2025Article
- Predicting Low Birth Weight in Big Cities in the United States Using a Machine Learning Approach.International journal of environmental research and public health · 2025Article
- PM2.5 Speciation Chemicals and Neonatal Respiratory Distress Syndrome (RDS): Uncovering the Interactions of Maternal Health, Environmental Metal Pollutants, and Sociodemographic Factors.Journal of occupational and environmental medicine · 2025Article
- The transcriptomic landscape of monosomy X (45,X) during early human fetal and placental development.Communications biology · 2025Article
- Article
- Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to studies undertaken over the past 40 years, low birthweight (LBW) is not only a significant predictor of perinatal death and morbidity, but also increases the risk of chronic non-communicable diseases (NCDs) in adulthood. The purpose of this paper is to summarize the research on LBW as a risk factor for NCDs in adults. The Barker hypothesis was based on the finding that adults with an LBW or an unhealthy intrauterine environment, as well as a rapid catch-up, die due to NCDs. Over the last few decades, terminology such as thrifty genes, fetal programming, developmental origins of health and disease (DOHaD), and epigenetic factors have been coined. The most common NCDs include cardiovascular disease, diabetes mellitus type 2 (DMT2), hypertension (HT), dyslipidemia, proteinuria, and chronic kidney disease (CKD). Studies in mothers who experienced famine and those that solely reported birth weight as a risk factor for mortality support the concept. Although the etiology of NCD is unknown, Barry Brenner explained the notion of a low glomerular number (nGlom) in LBW children, followed by the progression to hyperfiltration as the physiopathologic etiology of HT and CKD in adults based on Guyton's renal physiology work. Autopsies of several ethnic groups have revealed anatomopathologic evidence in fetuses and adult kidneys. Because of the renal reserve, demonstrating renal function in proportion to renal volume
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