Evidence map›Paper›PMID 35071054›Full record

ArticleFrontiers in cellular and infection microbiology2021

Trypanin Disruption Affects the Motility and Infectivity of the Protozoan

Jose L Saenz-Garcia, Beatriz S Borges, Normanda Souza-Melo, Luiz V Machado, Juliana S Miranda, Lisandro Alfonso Pacheco-Lugo, Nilmar S Moretti, Richard Wheleer, Lia C Soares Medeiros, Wanderson D DaRocha

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Axonemal dynein contributions to flagellar beat types and waveforms.bioRxiv : the preprint server for biology · 2025
    Article
  2. Kharon Is Crucial forPathogens (Basel, Switzerland) · 2025
    Article
  3. Synthesis and Anti-Molecules (Basel, Switzerland) · 2024
    Article
  4. Article
  5. CRISPR Genome Editing and the Study of Chagas Disease.Advances in experimental medicine and biology · 2023
    Article
  6. Gene editing of putative cAMP and CaThe Journal of eukaryotic microbiology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jose L Saenz-GarciaLaboratório de Genômica Funcional de Parasitos (GFP), Universidade Federal de Paraná, Curitiba, Brazil.
Beatriz S BorgesLaboratório de Biologia Celular, Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil.
Normanda Souza-MeloLaboratório de Biologia Molecular de Patógenos (LBMP), Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Luiz V MachadoLaboratório de Genômica Funcional de Parasitos (GFP), Universidade Federal de Paraná, Curitiba, Brazil.
Juliana S MirandaLaboratório de Genômica Funcional de Parasitos (GFP), Universidade Federal de Paraná, Curitiba, Brazil.
Lisandro Alfonso Pacheco-LugoFacultad de Ciencias Básicas y Biomédicas, Universidad Simón Bolívar, Barranquilla, Colombia.
Nilmar S MorettiLaboratório de Biologia Molecular de Patógenos (LBMP), Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Richard WheleerNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Lia C Soares MedeirosLaboratório de Biologia Celular, Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil.
Wanderson D DaRochaLaboratório de Genômica Funcional de Parasitos (GFP), Universidade Federal de Paraná, Curitiba, Brazil.

Funding

Wellcome Trust 211075/Z/18/Z
6 · The paper itself

Abstract

The flagellum of Trypanosomatids is an organelle that contributes to multiple functions, including motility, cell division, and host-pathogen interaction. Trypanin was first described in

Indexed as

Chagas DiseaseTrypanosoma brucei bruceiTrypanosoma cruziAnimalsFlagellaProtozoan ProteinsProtozoan ProteinsCRISPR-Cas9detached flagellummetacyclogenesismotilitySaCas9trypaninTrypanosoma cruzi (T. cruzi)

Identifiers

PMID35071054
PMCPMC8777028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.